Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

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dc.contributor.author Moura, Luciana Monteiro [UNIFESP]
dc.contributor.author Kempton, Matthew
dc.contributor.author Barker, Gareth
dc.contributor.author Salum, Giovanni
dc.contributor.author Gadelha, Ary [UNIFESP]
dc.contributor.author Pan, Pedro Mario [UNIFESP]
dc.contributor.author Hoexter, Marcelo Queiroz [UNIFESP]
dc.contributor.author Aquilla, Marco Antonio Gomes del [UNIFESP]
dc.contributor.author Picon, Felipe Almeida
dc.contributor.author Anes, Mauricio
dc.contributor.author Otaduy, Maria Concepcion Garcia
dc.contributor.author Amaro Junior, Edson
dc.contributor.author Rohde, Luis Augusto
dc.contributor.author McGuire, Philip
dc.contributor.author Bressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.author Sato, Joao Ricardo
dc.contributor.author Jackowski, Andrea Parolin
dc.date.accessioned 2020-07-22T13:23:05Z
dc.date.available 2020-07-22T13:23:05Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.mri.2015.12.021
dc.identifier.citation Magnetic Resonance Imaging. New York, v. 34, n. 4, p. 529-534, 2016.
dc.identifier.issn 0730-725X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56028
dc.description.abstract In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14 years of age. We investigated the associations between DTI parameters and MTR measure, to assess the myelination in the brain in development. Secondly, we investigated age-effects on DTI parameters (fractional anisotropy, axial, radial and mean diffusivities) and MTR. No significant correlations between MTR and DTI parameters were observed. In addition, a significant age-effect was detected for DTI data but was not visible for MTR data. Thereby, changes in white matter at this age might be primarily correlated with microstructural changes. (C) 2015 Elsevier Inc. All rights reserved. en
dc.description.sponsorship CAPES Foundation
dc.description.sponsorship Sao Paulo Research Foundation-FAPESP
dc.description.sponsorship CNPq, Brazil
dc.format.extent 529-534
dc.language.iso eng
dc.publisher Elsevier Science Inc
dc.relation.ispartof Magnetic Resonance Imaging
dc.rights Acesso restrito
dc.subject Magnetization transfer ratio en
dc.subject Diffusion tensor imaging en
dc.subject Normal brain development en
dc.subject Childhood en
dc.subject Adolescence en
dc.title Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570,1 Andar, BR-04039032 Sao Paulo, Brazil
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliation CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliation Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliation Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England
dc.description.affiliation Univ Sao Paulo, Lab Magnet Resonance Neuroradiol, LIM 44, Inst & Dept Radiol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570,1 Andar, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.sponsorshipID CAPES: 17930/12-0
dc.description.sponsorshipID FAPESP: 2013/10498-6
dc.description.sponsorshipID FAPESP: 2013/00506-1
dc.description.sponsorshipID FAPESP: 2013/08531-5
dc.description.sponsorshipID FAPESP: 2008/ 57896-8
dc.description.sponsorshipID CNPq: 573974/2008-0
dc.description.sponsorshipID CNPq: 442026/2014-5
dc.identifier.doi 10.1016/j.mri.2015.12.021
dc.description.source Web of Science
dc.identifier.wos WOS:000373095800024
dc.coverage New York
dc.citation.volume 34
dc.citation.issue 4



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