Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

Author Moura, Luciana Monteiro Autor UNIFESP Google Scholar
Kempton, Matthew Google Scholar
Barker, Gareth Google Scholar
Salum, Giovanni Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Aquilla, Marco Antonio Gomes del Autor UNIFESP Google Scholar
Picon, Felipe Almeida Google Scholar
Anes, Mauricio Google Scholar
Otaduy, Maria Concepcion Garcia Google Scholar
Amaro Junior, Edson Google Scholar
Rohde, Luis Augusto Google Scholar
McGuire, Philip Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Sato, Joao Ricardo Google Scholar
Jackowski, Andrea Parolin Google Scholar
Abstract In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14 years of age. We investigated the associations between DTI parameters and MTR measure, to assess the myelination in the brain in development. Secondly, we investigated age-effects on DTI parameters (fractional anisotropy, axial, radial and mean diffusivities) and MTR. No significant correlations between MTR and DTI parameters were observed. In addition, a significant age-effect was detected for DTI data but was not visible for MTR data. Thereby, changes in white matter at this age might be primarily correlated with microstructural changes. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Magnetization transfer ratio
Diffusion tensor imaging
Normal brain development
Childhood
Adolescence
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor CAPES Foundation
Sao Paulo Research Foundation-FAPESP
CNPq, Brazil
Grant number CAPES: 17930/12-0
FAPESP: 2013/10498-6
FAPESP: 2013/00506-1
FAPESP: 2013/08531-5
FAPESP: 2008/ 57896-8
CNPq: 573974/2008-0
CNPq: 442026/2014-5
Date 2016
Published in Magnetic Resonance Imaging. New York, v. 34, n. 4, p. 529-534, 2016.
ISSN 0730-725X (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 529-534
Origin http://dx.doi.org/10.1016/j.mri.2015.12.021
Access rights Closed access
Type Article
Web of Science ID WOS:000373095800024
URI https://repositorio.unifesp.br/handle/11600/56028

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account