Renal abnormalities in a cohort of HIV-infected children and adolescents

Renal abnormalities in a cohort of HIV-infected children and adolescents

Author Leão, Flavia Vanesca Felix Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Machado, Daisy Maria Autor UNIFESP Google Scholar
Gouvea, Aida de Fatima Thome Barbosa Autor UNIFESP Google Scholar
Carmo, Fabiana Bononi do Autor UNIFESP Google Scholar
Beltrao, Suenia Vasconcelos Autor UNIFESP Google Scholar
Cançado, Maria Aparecida de Paula Autor UNIFESP Google Scholar
Carvalhaes, Joo Tomas de Abreu Autor UNIFESP Google Scholar
Abstract Background This study aimed to identify the prevalence of renal abnormalities and the evolution of glomerular filtration rate (GFR) among human immunodeficiency virus (HIV)-infected children and adolescents followed up in an infectious disease outpatient pediatric clinic. Methods We performed a cohort study of 115 children and adolescents. Outcomes of two evaluations for urinalysis, microalbuminuria/urinary creatinine ratio, urinary retinol-binding protein (uRBP) concentration, and estimated GFR (eGFR) were obtained for each patient, with an average interval of 6 months between evaluations. These changes were correlated with gender, age, race, body mass index (BMI), height-for-age (H/A) percentile, clinical and immunological classification of HIV infection, use of antiretroviral therapy (ART), HIV viral load (VL), and CD4+ T-lymphocyte count. Results Mean patient age at the time of inclusion in the study was 12.6 +/- 3.2 years

50.4 % were male, 81.7 % had acquired immune defeciency syndrome (AIDS), 80.9 % had CD4+ < 500 cells/mm(3), and 87.8 % were on ART. Urinary changes included hematuria (11.3 %), proteinuria (7 %), and microalbuminuria (11.6 %)

uRBP was present in 3.8 %

and mean eGFR was 163 +/- 32 ml/min/1.73 m(2). Conclusions The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART.
Keywords Children
Human immunodeficiency virus
Renal dysfunction
Adolescents
Proteinuria
Hyperfiltration
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2016
Published in Pediatric Nephrology. New York, v. 31, n. 5, p. 773-778, 2016.
ISSN 0931-041X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 773-778
Origin http://dx.doi.org/10.1007/s00467-015-3260-x
Access rights Closed access
Type Article
Web of Science ID WOS:000373305100010
URI https://repositorio.unifesp.br/handle/11600/56026

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account