Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells (vol 9, 2018)

Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells (vol 9, 2018)

Author Caires-Junior, Luiz Carlos Google Scholar
Goulart, Ernesto Google Scholar
Melo, Uira Souto Google Scholar
Araujo, Bruno Henrique Silva Autor UNIFESP Google Scholar
Alvizi, Lucas Google Scholar
Soares-Schanoski, Alessandra Google Scholar
Oliveira, Danyllo Felipe de Google Scholar
Kobayashi, Gerson Shigeru Google Scholar
Griesi-Oliveira, Karina Google Scholar
Musso, Camila Manso Google Scholar
Amaral, Murilo Sena Google Scholar
Silva, Lucas Ferreira da Google Scholar
Astray, Renato Mancini Google Scholar
Suarez-Patino, Sandra Fernanda Google Scholar
Ventini, Daniella Cristina Google Scholar
Silva, Sergio Gomes da Google Scholar
Yamamoto, Guilherme Lopes Google Scholar
Ezquina, Suzana Google Scholar
Naslavsky, Michel Satya Google Scholar
Telles-Silva, Kayque Alves Google Scholar
Weinmann, Karina Google Scholar
van der Linden, Vanessa Google Scholar
van der Linden, Helio Google Scholar
Oliveira, Joao Ricardo Mendes de Google Scholar
Arrais, Nivia Maria Rodrigues Google Scholar
Melo, Adriana Google Scholar
Figueiredo, Thalita Google Scholar
Santos, Silvana Google Scholar
Meira, Joanna Goes Castro Google Scholar
Passos, Saulo Duarte Google Scholar
Almeida, Roque Pacheco de Google Scholar
Bispo, Ana Jovina Barreto Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Kalil, Jorge Google Scholar
Cunha-Neto, Edecio Google Scholar
Nakaya, Helder Google Scholar
Andreata-Santos, Robert Google Scholar
Ferreira, Luis Carlos de Souza Google Scholar
Verjovski-Almeida, Sergio Google Scholar
Ho, Paulo Lee Google Scholar
Passos-Bueno, Maria Rita Google Scholar
Zatz, Mayana Google Scholar
Abstract Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth. Whole-exome analysis in 18 affected CZS babies as compared to 5 unaffected twins and 609 controls excludes a monogenic model to explain resistance or increased susceptibility to CZS development. Overall, our results indicate that CZS is not a stochastic event and depends on NPC intrinsic susceptibility, possibly related to oligogenic and/or epigenetic mechanisms.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor CAPES
Date 2018
Published in Nature Communications. London, v. 9, 2018.
ISSN 2041-1723 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent -
Origin http://dx.doi.org/10.1038/s41467-017-02790-9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000427248800003a
URI https://repositorio.unifesp.br/handle/11600/55823

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