Sport-based physical activity recommendations and modifications in C-reactive protein and arterial thickness

Sport-based physical activity recommendations and modifications in C-reactive protein and arterial thickness

Author Cayres, Suziane Ungari Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Kemper, Han C. G. Google Scholar
Codogno, Jamile Sanches Google Scholar
Barbosa, Mauricio Fregonesi Autor UNIFESP Google Scholar
Fernandes, Romulo Araujo Google Scholar
Abstract We analyzed the effects of 1 year of engagement in >= 300 min/week of organized sports on inflammatory levels and vascular structure in adolescents. The sample was composed of 89 adolescents (11.6 +/- 0.7 years old [43 boys and 46 girls]), stratified according to engagement in >= 300 min/week of sport practice during at least 12 months of follow-up (n = 15, sport practice

n = 74, non-sport practice). Arterial thickness (carotid and femoral) was assessed by ultrasound scan, while high sensitive C-reactive protein levels were used to assess inflammatory status. Trunk fatness (densitometry scanner), biological maturation (age at peak height velocity), blood pressure, and skipping breakfast were treated as covariates. Independently of body fatness and biological maturation, the group engaged in sports presented a higher reduction in C-reactive protein (mean difference -1.559 mg/L [95%CI -2.539 to -0.579]) than the non-sport group (mean difference -0.414 mg/L [95%CI -0.846 to 0.017]) (p = 0.040). There was a significant relationship between changes in C-reactive protein and changes in femoral intima-media thickness in the non-sport group (r = 0.311 [95%CI 0.026 to 0.549]). Conclusion: Inflammation decreased in adolescents engaged in organized sports, independently of trunk fatness and biological maturation. Moreover, inflammation was related to arterial thickening only in adolescents not engaged in sports. What is Known: Intima media thickness is a relevant marker of cardiovascular disease in pediatric groups, being affected by obesity and inflammation. The importance of monitoring inflammatory markers from childhood is enhanced by the fact that alterations in these inflammatory markers in early life predict inflammation and alterations in carotid IMT in adulthood. What is New: Anti-inflammatory properties related to physical exercise performed at moderate intensity, on inflammation and alterations in IMT are not clear in pediatric groups. Due to the importance that sport participation has assumed as a promoter of improvements in health and quality of life, it is necessary to understand its potential benefits for cardiovascular health during human growth.
Keywords Adolescent
Inflammation
Arterial thickness
Cardiovascular health
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Sao Paulo Research Foundation-FAPESP
CNPq
Grant number FAPESP: 2013/06052-2
FAPESP: 2015/04961-0
CNPq: 476295/2013-0
CNPq: 303725/2014-1
Date 2018
Published in European Journal Of Pediatrics. New York, v. 177, n. 4, p. 551-558, 2018.
ISSN 0340-6199 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 551-558
Origin http://dx.doi.org/10.1007/s00431-018-3101-6
Access rights Closed access
Type Article
Web of Science ID WOS:000427367600011
URI https://repositorio.unifesp.br/handle/11600/55780

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