Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Author Soares, Glaucia Resende Autor UNIFESP Google Scholar
Moura, Carolina Foot Gomes de Autor UNIFESP Google Scholar
Silva, Marcelo Jose Dias Google Scholar
Vilegas, Wagner Google Scholar
Santamarina, Aline Boveto Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Abstract The aim of this study was to evaluate the chemopreventive potential of purple carrot extract following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO). For this purpose, histopathological analysis, proliferative status, antioxidant activity and inflammatory status were investigated in this setting. A total of 20 male rats were distributed into four groups as follows (n = 5 per group): Group 1-free access to water and commercial diet for 12 weeks

Group 2-received 4NQO at 50 ppm dose in drinking water daily and commercial diet for 12 weeks

Group 3-free access to water and received diet supplemented with purple carrot extract (0.1 g/kg) for 12 weeks

and Group 4-received 4NQO at 50 ppm dose in drinking water daily and diet supplemented with purple carrot extract (0.1 g/kg) for 12 weeks. Histopathological analysis revealed that animals treated with purple carrot extract reduced the oral lesions such as dysplasia and squamous cell carcinoma. Animals with oral pre-neoplastic lesions and treated with purple carrot extract decreased ki-67 and 8-OHdG immunoexpression. Moreover, pNF kappa Bp50 and MyD88 protein expressions were decreased after purple carrot treatment associated or not with 4NQO exposure. SOD-Mn mRNA levels increased with treatment with purple carrot extract as well. In conclusion, our results demonstrated that purple carrot extract was able to protect oral lesions induced by 4NQO in Wistar rats as a result of antioxidant activity, anti-inflammatory potential and antiproliferative and antimutagenic actions.
Keywords Oral cancer
Rat
4-Nitroquinoline 1-oxide
Purple carrot
Chemopreventive studies
xmlui.dri2xhtml.METS-1.0.item-coverage Totowa
Language English
Sponsor CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) fellowship
CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) fellowship
FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) fellowship
Date 2018
Published in Medical Oncology. Totowa, v. 35, n. 4, 2018.
ISSN 1357-0560 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent -
Origin http://dx.doi.org/10.1007/s12032-018-1114-7
Access rights Closed access
Type Article
Web of Science ID WOS:000428784500015
URI https://repositorio.unifesp.br/handle/11600/55750

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