Kidney-Derived c-Kit(+) Cells Possess Regenerative Potential

Kidney-Derived c-Kit(+) Cells Possess Regenerative Potential

Author Gomes, Samirah A. Google Scholar
Hare, Joshua M. Google Scholar
Rangel, Erika Bevilaqua Autor UNIFESP Google Scholar
Abstract Kidney-derived c-Kit(+) cells exhibit progenitor/stem cell properties in vitro (self-renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia-reperfusion injury and accelerate foot processes effacement reversal in a model of acute proteinuria in rats. Several mechanisms are involved in kidney regeneration by kidney-derived c-Kit(+ )cells, including cell engraftment and differentiation into renal-like structures, such as tubules, vessels, and podocytes. Moreover, paracrine mechanisms could also account for kidney regeneration, either by stimulating proliferation of surviving cells or modulating autophagy and podocyte cytoskeleton rearrangement through mTOR-Raptor and -Rictor signaling, which ultimately lead to morphological and functional improvement. To gain insights into the functional properties of c-Kit(+) cells during kidney development, homeostasis, and disease, studies on lineage tracing using transgenic mice will unveil their fate. The results obtained from these studies will set the basis for establishing further investigation on the therapeutic potential of c-Kit(+) cells for treatment of kidney disease in preclinical and clinical studies.
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Conselho Nacional em Pesquisa e Desenvolvimento (CNPq)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
European Foundation for the Study of Diabetes (EFSD)
Grant number CNPq: 456959/2013-0
FAPESP: 13/19560-6
Date 2018
Published in Stem Cells Translational Medicine. Hoboken, v. 7, n. 4, p. 317-324, 2018.
ISSN 2157-6564 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 317-324
Origin http://dx.doi.org/10.1002/sctm.17-0232
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000428344500001
URI https://repositorio.unifesp.br/handle/11600/55748

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