Double-blind evaluation of homeopathy on cocaine craving: a randomized controlled pilot study

Double-blind evaluation of homeopathy on cocaine craving: a randomized controlled pilot study

Author Adler, Ubiratan Cardinalli Google Scholar
Acorinte, Ana Carolina Google Scholar
Calzavara, Fernando Oliveira Google Scholar
Silva, Adriano Andre da Google Scholar
Cesar, Amarilys de Toledo Google Scholar
Adler, Maristela Schiabel Google Scholar
Martinez, Edson Zangiacomi Google Scholar
Galduróz, José Carlos Fernandes Autor UNIFESP Google Scholar
Abstract Background: Brazil is among the nations with the greatest rates of annual cocaine usage. Pharmacological treatment of cocaine addiction is still limited, opening space for nonconventional interventions. Homeopathic Q-potencies of opium and Erythroxylum coca have been tested in the integrative treatment of cocaine craving among homeless addicts, but this setting had not proven feasible, due to insufficient recruitment. Objective: This study investigates the effectiveness and tolerability of homeopathic Q-potencies of opium and E. coca in the integrative treatment of cocaine craving in a community-based psychosocial rehabilitation setting. Design, setting, participants, and interventions: A randomized, double-blind, placebo-controlled, parallel-group, eight-week pilot trial was performed at the Psychosocial Attention Center for Alcohol and Other Drugs (CAPS-AD), Sao Carlos/SP, Brazil. Eligible subjects included CAPS-AD patients between 18 and 65 years of age, with an International Classification of Diseases-10 diagnosis of cocaine dependence (F14.2). The patients were randomly assigned to two treatment groups: psychosocial rehabilitation plus homeopathic Q-potencies of opium and E. coca (homeopathy group), and psychosocial rehabilitation plus indistinguishable placebo (placebo group). Main outcome measures: The main outcome measure was the percentage of cocaine-using days. Secondary measures were the Minnesota Cocaine Craving Scale and 12-Item Short-Form Health Survey scores. Adverse events were reported in both groups. Results: The study population comprised 54 patients who attended at least one post-baseline assessment, out of the 104 subjects initially enrolled. The mean percentage of cocaine-using days in the homeopathy group was 18.1% (standard deviation (SD): 22.3%), compared to 29.8% (SD: 30.6%) in the placebo group (P < 0.01). Analysis of the Minnesota Cocaine Craving Scale scores showed no between-group differences in the intensity of cravings, but results significantly favored homeopathy over placebo in the proportion of weeks without craving episodes and the patients' appraisal of treatment efficacy for reduction of cravings. Analysis of 12-Item Short-Form Health Survey scores found no significant differences. Few adverse events were reported: 0.57 adverse events/patient in the homeopathy group compared to 0.69 adverse events/patient in the placebo group (P = 0.41). Conclusions: A psychosocial rehabilitation setting improved recruitment but was not sufficient to decrease dropout frequency among Brazilian cocaine treatment seekers. Psychosocial rehabilitation plus homeopathic Q-potencies of opium and E. coca were more effective than psychosocial rehabilitation alone in reducing cocaine cravings. Due to high dropout rate and risk of bias, further research is required to confirm our findings, with specific focus on strategies to increase patient retention. (C) 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
Keywords Homeopathy
Cocaine-related disorders
Clinical trial
Opium
Erythroxylum coca
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Date 2018
Published in Journal Of Integrative Medicine-Jim. Amsterdam, v. 16, n. 3, p. 178-184, 2018.
ISSN 2095-4964 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 178-184
Origin http://dx.doi.org/10.1016/j.joim.2018.03.004
Access rights Closed access
Type Article
Web of Science ID WOS:000432669500006
URI https://repositorio.unifesp.br/handle/11600/55552

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