Vaginal microbiota in asymptomatic Brazilian women with HIV

Vaginal microbiota in asymptomatic Brazilian women with HIV

Author Figueiredo Facundo, M. K. Autor UNIFESP Google Scholar
de Souza Bezerra Sakano, C. R. Autor UNIFESP Google Scholar
Nogueira de Carvalho, C. R. Autor UNIFESP Google Scholar
de Oliveira Machado, A. M. Autor UNIFESP Google Scholar
de Gois Speck, N. M. Autor UNIFESP Google Scholar
Lascasas Ribalta, J. Chamorro Autor UNIFESP Google Scholar
Abstract The purpose of this study was to evaluate the prevalence of different microorganisms, and the influence of menstrual cycle, CD4+ cells and viral load in vaginal flora, and compare different diagnosis methods in asymptomatic Human immunodeficiency virus HIV- and HIV+ women. Variables like contraception methods, type of sexual intercourse, and menstrual cycle phase were significant between groups. The clinical evaluation of vaginal pH and type of discharge, besides intraepithelial lesions, do not seem to have influence in microflora. Fresh wet-mount microscopy and bacterioscopy demonstrated no difference. HIV+ presented predominance of Gardnerella, Candida, Trichomonas, and Mobiluncus in cervicovaginal cytology, and vaginal culture exhibited higher prevalence of Gram+ and coagulase-negative staphylococci. Fresh wet mount microscopy showed a sensitivity of 88.9%, and the bacterioscopy sensitivity was 75%. Clinical exam specificities were 76.3% and 94.9%, respectively. Asymptomatic HIV+ women may present diversified vaginal microenvironment, possibly making them more prone to pelvic inflammatory disease, sexually transmitted infection (STI), and infertility.
Keywords HIV
Vaginal microenvironment
Bacterial vaginosis
LGT infection
Asymptomatic women
xmlui.dri2xhtml.METS-1.0.item-coverage Montreal
Language English
Sponsor CAPES grant
Date 2017
Published in Clinical And Experimental Obstetrics & Gynecology. Montreal, v. 44, n. 5, p. 704-709, 2017.
ISSN 0390-6663 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 704-709
Access rights Closed access
Type Article
Web of Science ID WOS:000410874100013

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