Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial

Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial

Author Silva, Lidia Aragao Google Scholar
Ferraz Carbonel, Adriana Aparecida Autor UNIFESP Google Scholar
Barbosa de Moraes, Andrea Regina Autor UNIFESP Google Scholar
Simoes, Ricardo S. Google Scholar
da Silva Sasso, Gisela Rodrigues Autor UNIFESP Google Scholar
Goes, Livia Autor UNIFESP Google Scholar
Nunes, Winnie Autor UNIFESP Google Scholar
Simoes, Manuel Jesus{UNIFESP] Google Scholar
Patriarca, Marisa Teresinha Autor UNIFESP Google Scholar
Abstract Objective: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy.Methods: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N=30) 45-55year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of SAo Paulo (UNIFESP). The Ethical Committee of the Federal University of SAo Paulo approved the study (report no. 386/2004

registration on ClinicalTrials.gov NCT01553773), were assigned to topical treatment with either estrogen or genistein for 24weeks. We quantified and compared facial collagen concentration before and after each treatment by performing pre-auricular skin biopsies.Results: Our data showed an increase in the amount of both type I and type III facial collagen by the end of both treatments. However, the outcomes of the estrogen GI (ER) group were superior to the genistein GII (GEN) group, with statistical significance p<000.1Conclusion: Treatment with topical estrogen is superior to genistein, but both have positive impacts on facial skin collagen. Nevertheless, it is still unclear whether prolonged use of genistein and other topical phytoestrogens could produce systemic effects and further research is needed to clarify this question.
Keywords Collagen
estrogens
genistein
menopause
face
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Date 2017
Published in Gynecological Endocrinology. Abingdon, v. 33, n. 11, p. 845-848, 2017.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 845-848
Origin http://dx.doi.org/10.1080/09513590.2017.1320708
Access rights Closed access
Type Article
Web of Science ID WOS:000415815100005
URI https://repositorio.unifesp.br/handle/11600/55432

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account