Renin angiotensin system and cardiac hypertrophy after sinoaortic denervation in rats

Renin angiotensin system and cardiac hypertrophy after sinoaortic denervation in rats

Author Piratello, Aline Cristina Autor UNIFESP Google Scholar
Moraes-Silva, Ivana Cinthya Autor UNIFESP Google Scholar
Paulini, Janaina Google Scholar
Souza, Pamella Ramona Google Scholar
Sirvente, Raquel Google Scholar
Salemi, Vera Google Scholar
Flues, Karin Google Scholar
Moreira, Edson Dias Google Scholar
Mostarda, Cristiano Autor UNIFESP Google Scholar
Cunha, Tatiana Sousa Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Irigoyen, Maria Claudia Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: The aim of this study was to evaluate the role of angiotensin I, II and 1-7 on left ventricular hypertrophy of Wistar and spontaneously hypertensive rats submitted to sinoaortic denervation. METHODS: Ten weeks after sinoaortic denervation, hemodynamic and morphofunctional parameters were analyzed, and the left ventricle was dissected for biochemical analyses. RESULTS: Hypertensive groups (controls and denervated) showed an increase on mean blood pressure compared with normotensive ones (controls and denervated). Blood pressure variability was higher in denervated groups than in their respective controls. Left ventricular mass and collagen content were increased in the normotensive denervated and in both spontaneously hypertensive groups compared with Wistar controls. Both hypertensive groups presented a higher concentration of angiotensin II than Wistar controls, whereas angiotensin 1-7 concentration was decreased in the hypertensive denervated group in relation to the Wistar groups. There was no difference in angiotensin I concentration among groups. CONCLUSION: Our results suggest that not only blood pressure variability and reduced baroreflex sensitivity but also elevated levels of angiotensin II and a reduced concentration of angiotensin 1-7 may contribute to the development of left ventricular hypertrophy. These data indicate that baroreflex dysfunction associated with changes in the renin angiotensin system may be predictive factors of left ventricular hypertrophy and cardiac failure.
Keywords Angiotensins
Left ventricular hypertrophy
Spontaneously hypertensive rats
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 151558/2007-8
Date 2010-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 65, n. 12, p. 1345-1350, 2010.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 1345-1350
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000288493400019
SciELO ID S1807-59322010001200019 (statistics in SciELO)

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