Birth Weight and Its Relationship with the Cardiac Autonomic Balance in Healthy Children

Birth Weight and Its Relationship with the Cardiac Autonomic Balance in Healthy Children

Author Souza, Livia Victorino Autor UNIFESP Google Scholar
Oliveira, Vanessa Autor UNIFESP Google Scholar
De Meneck, Franciele Autor UNIFESP Google Scholar
Grotti Clemente, Ana Paula Google Scholar
Louzada Strufaldi, Maria Wany Autor UNIFESP Google Scholar
Franco, Maria do Carmo Autor UNIFESP Google Scholar
Abstract Several studies indicate that the fetal environment plays a significant role in the development of cardiometabolic disease later in life. However, a few studies present conflicting data about the correlation between birth weight and the impairment of cardiac autonomic modulation. The purpose of the present study was to provide further knowledge to elucidate this contradictory relationship. One hundred children aged 5 and 14 years had anthropometric parameters, body composition and blood pressure levels determined. Heart rate variability (HRV) was evaluated by heart rate monitoring, including measurements of both the time and frequency domains. The results showed inverse correlation between the HRV parameters with BMI (RMSSD: P = 0.047

PNN50: P = 0.021

HF: P = 0.041), systolic (RMSSD: P = 0.023

PNN50: P = 0.032) and diastolic (PNN50: P = 0.030) blood pressure levels. On the other hand, there were consistent positive correlations between the HRV parameters and birth weight (RMSSD: P = 0.001

PNN50: P = 0.001

HF: P = 0.002). To determine the effect of birth weight on HRV parameters, we perform multivariate linear regression analysis adjusted for potentially confounding factors (prematurity, gender, age, BMI, physical activity index and SBP levels). These findings were preserved even after adjusting for these confounders. Our results suggested that impaired cardiac autonomic modulation characterized by a reduction in the parasympathetic activity occurs in children with low birth weight. One possible interpretation for these data is that a vagal withdrawal, rather than a sympathetic overactivity, could precede the development of hypertension and other cardiometabolic diseases in children with low birth weight. However, long-term studies should be performed to investigate this possibility.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Sponsor FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)
Grant number FAPESP: 2013/03139-0
Date 2017
Published in Plos One. San Francisco, v. 12, n. 1, p. -, 2017.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000392372300004

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