A rare case of TFE-related pigmented renal tumor with overlapping features between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma with melanotic features

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dc.contributor.author Cardili, Leonardo [UNIFESP]
dc.contributor.author Pereira, Gregorio Wrublevsky
dc.contributor.author Viana, Cristiano Ribeiro
dc.date.accessioned 2020-07-17T14:02:31Z
dc.date.available 2020-07-17T14:02:31Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1111/pin.12517
dc.identifier.citation Pathology International. Hoboken, v. 67, n. 4, p. 208-213, 2017.
dc.identifier.issn 1320-5463
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54846
dc.description.abstract In recent years, an increasing number of TFE3 rearrangement-associated tumors with melanotic features have been reported as primary neoplasm in different anatomical sites, including the kidney. Melanotic Xp11 translocation renal cancer (MXTRC) and Xp11 renal cell carcinoma with melanotic features (XRCCM) have been proposed to be main categories for pigmented lesions in the microophthalmia-associated transcription factor (MiTF/TFE3) family of renal tumors that may show variable degrees of melanocytic differentiation. Herein we report a rare case of TFE3-related pigmented renal tumor showing unusual immunoexpression of cytokeratins (AE1/AE3) and renal cell carcinoma markers (RCC, CD10). Cathepsin-K and Vimentin were diffusely positive whereas melanocytic markers (HMB-45 and Melan-A) displayed weak and patchy expression. We found no labelling for PAX-8, muscle markers (desmin, smooth muscle actin, muscle-specific actin and caldesmon) and S-100. TFE3 fusion was confirmed by break-apart fluorescence in situ hybridization (FISH). This case corroborates previous evidence for overlap in the TFE3-associated cancer family and illustrates that it may not be possible to set a clear cutoff between epithelial (XRCCM) and mesenchymal (MXTRC) subgroups. en
dc.format.extent 208-213
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Pathology International
dc.rights Acesso restrito
dc.subject kidney en
dc.subject melanin en
dc.subject neoplasms en
dc.subject TFE3 en
dc.subject Xp11 en
dc.title A rare case of TFE-related pigmented renal tumor with overlapping features between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma with melanotic features en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo EPM UNIFESP, Dept Pathol, Escola Paulista Med, R Botucatu,740 Ed Lemos Torres,1 Andar, BR-04023900 Sao Paulo, Brazil
dc.description.affiliation GRAAC, IOP, Sao Paulo, Brazil
dc.description.affiliation Fundacao Pio XII, Dept Pathol, Hosp Canc Barretos, Barretos, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo EPM UNIFESP, Dept Pathol, Escola Paulista Med, R Botucatu,740 Ed Lemos Torres,1 Andar, BR-04023900 Sao Paulo, Brazil
dc.identifier.doi 10.1111/pin.12517
dc.description.source Web of Science
dc.identifier.wos WOS:000398594700004
dc.coverage Hoboken
dc.citation.volume 67
dc.citation.issue 4



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