Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study

Physiological and cytokine response to acute exercise under hypoxic conditions: a pilot study

Author Lira, Fabio Santos de Google Scholar
Lemos, Valdir de Aquino Autor UNIFESP Google Scholar
Bittar, Irene Guarido Luz Autor UNIFESP Google Scholar
Caris, Aline Venticinque Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Zagatto, Alessandro M. Google Scholar
Souza, Claudio Teodoro de Google Scholar
Pimentel, Gustavo Duarte Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Abstract BACKGROUND: Studies have demonstrated that exercise in hypoxia situations induces a cytotoxicity effects. However, the cytokines participation in this condition is remaining unknown. Thus, the aim the present study was to evaluate physiological parameters and inflammatory profiles in response to acute exercise after five hours of hypoxic conditions. METHODS: Fourteen healthy men were distributed randomly into two groups: normoxic exercise (N.=7) and hypoxic exercise (N.=7). All volunteers were blinded to the protocol. Initially, all subjects were submitted to chamber normobaric in a room fitted for altitude simulations of up to 4500 m, equivalent to a barometric pressure of 433 mmHg. All analyses began at 7:00 a.m. and was maintained for 5 hours; the fraction of inspired oxygen (FiO2) was 13.5%. The groups began a 60-minute session of physical exercise starting at 11:00 a.m., at 50% of peak VO2 (50% VO2peak). Blood was collected for cytokine analysis in the morning upon waking, before the 60-minute exercise session and immediately thereafter. RESULTS: The heart rate during 60 minutes’ exercise training was significantly increased in both exercise groups (P<0.05), and the oxygen saturation was reduced under hypoxic conditions during exercise (P<0.05). After exercise, significant increases were found for IL-1ra and IL-10 under hypoxic conditions (P<0.05) and for IL-6 for both groups (P<0.05). TNF-α was not altered under either environmental condition. CONCLUSIONS: Our data demonstrate that acute exercise performance in hypoxic conditions can promotes early inflammatory response, leads for immunosuppression state
Keywords Hypoxia
Exercise
Cytokines
xmlui.dri2xhtml.METS-1.0.item-coverage Turin
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/19026-1
Date 2017
Published in Journal of Sports Medicine and Physical Fitness. Turin, v. 57, n. 4, p. 461-468, 2017.
ISSN 0022-4707 (Sherpa/Romeo, impact factor)
Publisher Edizioni Minerva Medica
Extent 461-468
Origin https://dx.doi.org/10.23736/S0022-4707.16.06073-X
Access rights Closed access
Type Article
Web of Science ID WOS:000404529100019
URI https://repositorio.unifesp.br/handle/11600/54779

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