Outcomes from a cohort of patients with acute kidney injury subjected to continuous venovenous hemodiafiltration: The role of negative fluid balance

Outcomes from a cohort of patients with acute kidney injury subjected to continuous venovenous hemodiafiltration: The role of negative fluid balance

Author Claizoni dos Santos, Thais Oliveira Autor UNIFESP Google Scholar
de Souza Oliveira, Marisa Aparecida Autor UNIFESP Google Scholar
Martins Monte, Julio Cesar Google Scholar
Batista, Marcelo Costa Autor UNIFESP Google Scholar
Pereira Junior, Virgilio Goncalves Google Scholar
Cardoso dos Santos, Bento Fortunato Google Scholar
Pavao Santos, Oscar Fernando Autor UNIFESP Google Scholar
Durao Junior, Marcelino de Souza Autor UNIFESP Google Scholar
Abstract Background Several factors influence the outcomes in acute kidney injury (AKI), especially in intensive care unit (ICU) patients. In this scenario, continuous renal replacement therapies (CRRT) are used to control metabolic derangements and blood volume. Knowing this fact, it may be possible to change the course of the disease and decrease the high mortality rate observed. Thus, we aimed to evaluate the main risk factors for death in AKI patients needing CRRT. Results This was a prospective, observational cohort study of ICU patients (N = 183) with AKI who underwent continuous venovenous hemodiafiltration (CVVHDF) as their initial dialysis modality choice. The patients were predominantly male (62.8%) and their median age was 65 (55-76) years. The most frequent comorbidities were cardiovascular disease (39.3%), hypertension (32.8%), diabetes (24%), and cirrhosis (20.7%). The main cause of AKI was sepsis (52.5%). At beginning of CVVHDF, 152 patients (83%) were using vasopressors. The median SAPS 3 and SOFA score at ICU admission was 61 (50-74) and 10 (7-12), respectively. The dialysis dose delivered was 33.2 (28.9-38.7) ml/kg/h. The median time between ICU admission and CVVHDF initiation was 2 (1-4) days. The median cumulative fluid balance during the CVVHDF period was -1838 (-5735 +2993) ml. The mortality rate up to90 days was 58%. The independent mortality risk factors in propensity score model were: chronic obstructive pulmonary disease (OR = 3.44[1.14-10.4

p = 0.028]), hematologic malignancy (OR = 5.14[1.66-15.95

p = 0.005]), oliguria (OR = 2.36[1.15-4.9

p = 0.02]), positive daily fluid balance during CVVHDF (OR = 4.55[2.75-13.1

p < 0.001]), and total SOFA score on first dialysis day (OR = 1.27[1.12-1.45

p < 0.001]). Conclusions Dialysis-related factors may influence the outcomes. In our cohort, positive daily fluid balance during CRRT was associated with lower survival. Multicenter, randomized studies are needed to assess fluid balance as a primary outcome to define the best strategy in this patient population.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Sponsor Fundacao de Ampan a Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number FAPESP: 2012/19020-9
Date 2017
Published in Plos One. San Francisco, v. 12, n. 4, p. -, 2017.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Origin http://dx.doi.org/10.1371/journal.pone.0175897
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000399875900066
URI https://repositorio.unifesp.br/handle/11600/54712

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