Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy

Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy

Author Palma, Luiz Felipe Autor UNIFESP Google Scholar
Stabile Gonnelli, Fernanda Aurora Autor UNIFESP Google Scholar
Marcucci, Marcelo Google Scholar
Dias, Rodrigo Souza Google Scholar
Giordani, Adelmo Jose Autor UNIFESP Google Scholar
Segreto, Roberto Araujo Autor UNIFESP Google Scholar
Comodo Segreto, Helena Regina Autor UNIFESP Google Scholar
Abstract Late effects of radiotherapy for head and neck cancer treatment have been increasingly investigated due to its impact on patients' quality of life. The purpose of this study was to evaluate the effect of low-level laser therapy on hyposalivation, low salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Twenty-nine patients with radiation-induced xerostomia received laser sessions twice a week, during 3 months (24 sessions). For this, a continuous wave Indium-Gallium-Aluminium-Phosphorus diode laser device was used punctually on the major salivary glands (808 nm, 0.75 W/cm(2), 30 mW, illuminated area 0.04 cm(2), 7.5 J/cm(2), 10 s, 0.3 J). Six extraoral points were illuminated on each parotid gland and three on each submandibular gland, as well as two intraoral points on each sublingual gland. Stimulated and unstimulated salivary flow rate, pH (two scales with different gradations), and quality of life (University Of Washington Quality of Life Questionnaire for Patients with Head and Neck Cancer) were assessed at baseline and at the end of the treatment. There were significant increases in both mean salivary flow rates (unstimulated: p = 0.0012

stimulated: p < 0.0001), mean pH values (p = 0.0002 and p = 0.0004), and mean score from the quality of life questionnaire (p < 0.0001). Low-level laser therapy seems to be effective to mitigate salivary hypofunction and increase salivary pH of patients submitted to radiotherapy for head and neck cancer, thereby leading to an improvement in quality of life.
Keywords Head and neck neoplasms
Low-level light therapy
Radiotherapy
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2017
Published in Lasers In Medical Science. London, v. 32, n. 4, p. 827-832, 2017.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer London Ltd
Extent 827-832
Origin http://dx.doi.org/10.1007/s10103-017-2180-3
Access rights Closed access
Type Article
Web of Science ID WOS:000399885100011
URI https://repositorio.unifesp.br/handle/11600/54683

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