Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

Author Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Gomes, Guiomar N. Google Scholar
Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Abstract It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9

p < 0.05, n = 6) with no changes in heart rate (HR). Sympathetic nerve activity was increased at different levels to the remaining kidney, splanchnic and lumbar beds compared to control (CTL) group (CKD rSNA: 150 +/- 50, n = 9 vs. CTL 96 +/- 15, n = 9

CKD sSNA: 129 +/- 51, n = 5 vs. CTL 34 +/- 14, n = 6

CKD ISNA: 203 +/- 35, n = 8 vs. CTL 146 +/- 21, spikes/s, n = 7, p < 0.05). Three weeks after total renal denervation (DNX) MAP was normalized in the CKD rats (124 +/- 19 mm Hg, n = 5, p < 0.05), with no change in HR. The ISNA was normalized (151 +/- 40, n = 5, vs. CKD 203 +/- 35 spikes/s, n = 8) and sSNA was decreased in 49% (64 +/- 34, n = 5 vs. CKD 129 +/- 51 spikes/s, n = 5, p < 0.05). Renal function, assessed by creatinine plasma levels was improved after renal denervation (CKD 1.50 +/- 0.64, n = 8

vs. CKD + DNX 0.82 +/- 0.22 mg/mL, n = 8, p < 0.05). These findings demonstrate that renal nerves contribute to the maintenance of hypertension in CKD by increasing sympathoexcitation to other beds. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Chronic kidney disease
Hypertension
Sympathetic activity
Renal afferent activation
Renal denervation
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Sao Paulo Research Foundation
CNPq fellowships
FAPESP
CAPES-PNPD Postdoctoral Fellowships
Grant number FAPESP: 2013/22522-9
FAPESP: 2013/23741-6
Date 2017
Published in Autonomic Neuroscience-Basic & Clinical. Amsterdam, v. 204, p. 81-87, 2017.
ISSN 1566-0702 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 81-87
Origin http://dx.doi.org/10.1016/j.autneu.2016.11.006
Access rights Closed access
Type Article
Web of Science ID WOS:000400219400010
URI https://repositorio.unifesp.br/handle/11600/54616

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