Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome

Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome

Author Topcuoglu, Mehmet Akif Google Scholar
Chan, Suk-tak Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Smith, Eric Edward Google Scholar
Kwong, Kenneth K. Google Scholar
Singhal, Aneesh Bhim Google Scholar
Abstract Background: Altered cerebrovascular tone is implicated in reversible cerebral vasoconstriction syndrome (RCVS). We evaluated vasomotor reactivity using bedside transcranial Doppler in RCVS patients. Methods: In this retrospective case-control study, middle cerebral artery (MCA) blood flow velocities were compared at rest and in response to breath-hold in RCVS (n=8), Migraineurs (n=10), and non-headache Controls (n=10). Hyperventilation response was measured in RCVS. Results: In RCVS, Breath Holding Index (BHI) was severely reduced in seven of eight patients and 14/16 MCAs

seven of 16 MCAs showed exhausted (BHI<0.1) or inverted (BHI<0) vasomotor reactivity. Mean BHI in RCVS (0.23 +/- 0.5) was significantly lower than Migraine (1.52 +/- 0.57) and Controls (1.51 +/- 0.32), p<0.001. Triphasic velocity responses were seen in all groups. The maximum V-mean decline during the middle negative phase was -15.5 +/- 9.2% in RCVS, -15.4 +/- 7% in Migraine, and -10.3 +/- 5% in Controls (p=0.04). In the late positive phase, average V-mean increase was 6.2 +/- 14% in RCVS, which was significantly lower (p<0.001) than Migraine (30.5 +/- 11%) and Controls (30.2 +/- 6%). With hyperventilation, RCVS patients showed 23% decrease in V-mean. Conclusion: Cerebral arterial tone is abnormal in RCVS, with proximal vasoconstriction and abnormally reduced capacity for vasodilation. Further studies are needed to determine the utility of BHI to diagnose RCVS before angiographic reversibility is established, and to estimate prognosis.
Keywords Reversible cerebral vasoconstriction syndrome
transcranial Doppler
cerebrovascular reactivity
breath-hold challenge
migraine
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2017
Published in Cephalalgia. London, v. 37, n. 6, p. 541-547, 2017.
ISSN 0333-1024 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 541-547
Origin http://dx.doi.org/10.1177/0333102416650706
Access rights Closed access
Type Article
Web of Science ID WOS:000401026600006
URI https://repositorio.unifesp.br/handle/11600/54597

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