Efficacy and safety of a video-EEG protocol for genetic generalized epilepsies

Efficacy and safety of a video-EEG protocol for genetic generalized epilepsies

Author De Marchi, Luciana Rodrigues Autor UNIFESP Google Scholar
Corso, Jeana Torres Autor UNIFESP Google Scholar
Zetehaku, Ana Carolina Autor UNIFESP Google Scholar
Pedroso Uchida, Carina Goncalves Autor UNIFESP Google Scholar
Bittar Guaranha, Mirian Salvadori Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Abstract Introduction: Video-EEG has been used to characterize genetic generalized epilepsies (GGE). For best performance, sleep recording, photic stimulation, hyperventilation, and neuropsychological protocols are added to the monitoring. However, risks and benefits of these video-EEG protocols are not well established. The aim of this study was to analyze the efficacy and safety of a video-EEG neuropsychological protocol (VNPP) tailored for GGE and compare its value with that of routine EEG (R-EEG). Methods: We reviewed the VNPP and R-EEG of patients with GGE. We considered confirmation of the clinical suspicion of a GGE syndrome and characterization of reflex traits as benefits

and falls, injuries, psychiatric and behavioral changes, generalized tonic-clonic (GTC) seizures, and status epilepticus (SE) as the main risks of the VNPP. Results: The VNPPs of 113 patients were analyzed. The most common epileptic syndrome was juvenile myoclonic epilepsy (85.8%). The protocol confirmed a GGE syndrome in 97 patients and 62 had seizures. Sleep recording had a provocative effect in 51.2% of patients. The second task that showed highest efficacy was praxis (39.3%) followed by hyperventilation (313%). Among the risks, 1.8% had GTC seizures and another 1.8%, SE. Eighteen percent of patients had persistently normal R-EEG, 72.2% of them had discharges during VNPP. Generalized tonic-clonic seizures, myoclonic status epilepticus, and repeated seizures were the main risks of VNPP present in 6 (5.31%) patients while there were no complications during R-EEG. Conclusions: The VNPP in GGE is a useful tool in diagnosis and characterization of reflex traits, and is a safe procedure. Its use might preclude multiple R-EEG exams. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Video-EEG neuropsychological protocol
Genetic generalized epilepsy
Routine EEG
Reflex traits
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) from Brazil
Fundacao Capes from Brazil
Grant number CAPES: 90881
Date 2017
Published in Epilepsy & Behavior. San Diego, v. 70, p. 187-192, 2017.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 187-192
Origin http://dx.doi.org/10.1016/j.yebeh.2017.03.029
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000402447700032
URI https://repositorio.unifesp.br/handle/11600/54561

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