Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches

Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches

Author Correa-Velloso, Juliana C. Google Scholar
Goncalves, Maria C. B. Autor UNIFESP Google Scholar
Naaldijk, Yahaira Google Scholar
Oliveira-Giacomelli, Agatha Google Scholar
Pillat, Micheli M. Google Scholar
Ulrich, Henning Google Scholar
Abstract Neuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be critical for the progression of those disorders, which are based on genetic and epigenetic mechanisms as well as on extrinsic factors. We review here common mechanisms underlying the comorbidity of Bipolar Disorders and Alzheimer's Disease, such as aberrant neurogenesis and neurotoxicity, reporting current therapeutic approaches. The understanding of these mechanisms precedes stem cell-based strategies as a new therapeutic possibility for treatment and prevention of Bipolar and Alzheimer's Disease progression. Taking into account the difficulty of studying the molecular basis of disease progression directly in patients, we also discuss the importance of stem cells for effective drug screening, modeling and treating psychiatric diseases, once in vitro differentiation of patient-induced pluripotent stem cells provides relevant information about embryonic origins, intracellular pathways and molecular mechanisms.
Keywords Bipolar Disorder
Alzheimer's Disease
Stem cell therapy
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Sao Paulo Research State Foundation FAPESP
National Council for Scientific and Technological Development CNPq, Brazil
Grant number FAPESP: 2012/50880-4
CNPq: 306429/2013-6
CNPq: 141979/2014-3, 870458/1997-3
FAPESP: 2015/19478-3, 2015/14343-2
Date 2018
Published in Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 80, p. 34-53, 2018.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 34-53
Access rights Closed access
Type Article
Web of Science ID WOS:000414025900006

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