Association between obesity and sleep disorders in postmenopausal women

Association between obesity and sleep disorders in postmenopausal women

Author Naufel, Maria Fernanda Autor UNIFESP Google Scholar
Frange, Cristina Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Batista Castello Girao, Manoel Joao Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Abstract Objective:To investigate the relationship between obesity and sleep architecture in postmenopausal women.Methods:One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), and neck circumference. Participants were allocated into two groups according to BMI: nonobese group (BMI <30kg/m(2)) and obese group (BMI 30kg/m(2)).Results:The obese group had significantly (P<0.01) increased values of BMI, neck circumference, waist circumference, and hip circumference. WHR was similar between the groups (P=0.77). Obese participants had significantly increased values of respiratory disturbance index (16.4 vs 9.3n degrees/h) and apnea-hypopnea index (14.2 vs 5.6n degrees/h). Rapid eye movement sleep latency was positively correlated to body mass (r=P<0.01), BMI (P<0.01), and hip circumference (P=0.01). WHR was negatively correlated to sleep efficiency (P=0.03). The linear regression model showed that BMI (P<0.01) and WHR (P<0.01) were positive predictors of rapid eye movement sleep latency.Conclusion:In postmenopausal women, high BMI and abdominal obesity are sources of sleep disturbances, decreasing deep sleep, and sleep efficiency, while increasing the risk of obstructive sleep apnea.
Keywords Insomnia
Menopause
Obesity
Postmenopause
Sleep
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
CNPq
Sao Paulo Research Foundation (FAPESP)
Grant number Conselho Nacional de Desenvolvimento Cientifico e Tecnologico: 158506/2014-6, 453924/2014-0
FAPESP: 2014/18722-5
Date 2018
Published in Menopause-The Journal Of The North American Menopause Society. Philadelphia, v. 25, n. 2, p. 139-144, 2018.
ISSN 1072-3714 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 139-144
Origin http://dx.doi.org/10.1097/GME.0000000000000962
Access rights Closed access
Type Article
Web of Science ID WOS:000424082900005
URI https://repositorio.unifesp.br/handle/11600/54217

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