Assessing cardiovascular risk in ATM heterozygotes

Assessing cardiovascular risk in ATM heterozygotes

Author de Almeida Kotchetkoff, Elaine Cristina Autor UNIFESP Google Scholar
Suano de Souza, Fabiola Isabel Autor UNIFESP Google Scholar
Affonso Fonseca, Fernando Luiz Autor UNIFESP Google Scholar
Hix, Sonia Google Scholar
Ajzen, Sergio Aron Autor UNIFESP Google Scholar
Shigueoka, David Carlos Autor UNIFESP Google Scholar
Costa Carvalho, Beatriz Tavares Autor UNIFESP Google Scholar
Saccardo Sarni, Roseli Oselka Autor UNIFESP Google Scholar
Abstract Objective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 +/- 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]

p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations.
Keywords Ataxia Telangiectasia
Atherosclerosis
Carotid Intima-Media Thickness
Insulin Resistance
Heterozygote
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Date 2018
Published in Revista Da Associacao Medica Brasileira. Sao Paulo, v. 64, n. 2, p. 148-153, 2018.
ISSN 0104-4230 (Sherpa/Romeo, impact factor)
Publisher Assoc Medica Brasileira
Extent 148-153
Origin http://dx.doi.org/10.1590/1806-9282.64.02.148
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000429487700011
SciELO ID S0104-42302018000200148 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/54153

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