Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative

Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative

Author Guimaraes, Julio Brandao Autor UNIFESP Google Scholar
Nevitt, Michael C. Google Scholar
McCulloch, Charles E. Google Scholar
Schwaiger, Benedikt J. Google Scholar
Gersing, Alexandra S. Google Scholar
Facchetti, Luca Google Scholar
Bucknor, Matthew D. Google Scholar
Chanchek, Nattagan Google Scholar
Liu, Felix Google Scholar
Joseph, Gabby B. Google Scholar
Link, Thomas M. Google Scholar
Abstract To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (ae<yen>3%, n = 141), had moderate weight gain (3-10%, n = 77), substantial weight gain (> 10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects' characteristics. Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9

95% confidence interval [CI] 2.4-8.9) and substantial weight gain (OR, 9.5

95% CI 3.2-28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8

95% CI 3.5-11.3

lateral: OR, 2.6

95% CI 1.1-6.6) and substantial weight gain (medial: OR, 21.0

95% CI 5.1-80.7

lateral: OR, 9.7

95% CI 0.95-100.2). Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain.
Keywords Magnetic resonance imaging
Meniscal intrasubstance degeneration
Meniscal tears
Weight change
Meniscal lesion
BMI
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor National Institutes of Health, a branch of the Department of Health and Human Services
Pfizer, Inc.
Novartis Pharmaceuticals Corporation
Merck Research Laboratories
GlaxoSmithKline
Foundation for the National Institutes of Health
Grant number National Institutes of Health: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
Date 2018
Published in European Radiology. New York, v. 28, n. 3, p. 953-962, 2018.
ISSN 0938-7994 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 953-962
Origin http://dx.doi.org/10.1007/s00330-017-5054-y
Access rights Closed access
Type Article
Web of Science ID WOS:000424997600007
URI https://repositorio.unifesp.br/handle/11600/54062

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