Differential effects of renal denervation on arterial baroreceptor function in Goldblatt hypertension model

Differential effects of renal denervation on arterial baroreceptor function in Goldblatt hypertension model

Author Lincevicius, Gisele S. Autor UNIFESP Google Scholar
Shimoura, Caroline G. Autor UNIFESP Google Scholar
Nishi, Erika E. Autor UNIFESP Google Scholar
Oliveira, Tales Autor UNIFESP Google Scholar
Cespedes, Juliana G. Autor UNIFESP Google Scholar
Bergamaschi, Cassia T. Autor UNIFESP Google Scholar
Campos, Ruy R. Autor UNIFESP Google Scholar
Abstract Sympathetic vasomotor activity is significantly increased in renovascular hypertension. Renal denervation (DnX) has emerged as a novel therapy for resistant hypertension to drug therapy. However, the underlying mechanisms regarding the reduction in blood pressure (BP) after DnX remain unclear. Thus, the aim of this study was to evaluate the effects of DnX of a clipped kidney on the baseline and baroreceptor reflex control of post -ganglionic sympathetic activity to the contralateral kidney (rSNA) and lumbar (lSNA) nerves in Goldblatt hypertensive rats (2K1C). Renal denervation of an ischaemic kidney (DxX - all visible bundles of nerves were dissected 10% phenol) was performed 5 weeks after clipping (gap width: 0.2 mm). Ten days after DnX, BP was significantly reduced (16%) in the 2K1C compared with the undenervated 2K1C (p < 0.05). DnX significantly reduced basal rSNA (control group (CT): 110 +/- 8, n = 14

2K1C: 150 +/- 8, n = 12

2K1C DnX: 89 +/- 7, spikes per second (spikes/s)

p < 0.05, n = 8) and lSNA (CT: 137 +/- 8, n = 8

2K1C: 202 +/- 7, n = 11

2K1C DnX: 131 +/- 7, spikes/s

p < 0.05, n = 8) only in 2K1C rats. DnX significantly improved the arterial baroreceptor sensitivity of rSNA (CT: -2.3 +/- 0.2, n = 11

2K1C: -0.7 +/- 0.1, n = 8

2K1C DnX: 1.5 +/- 0.2, spikes/s/mm Hg

p < 0.05, n = 5) and heart rate for tachycardic response (CT: -3.9 +/- 0.5, n = 7

2K1C: -1.9 +/- 0.1, n = 8

2K1C DnX: -3.3 +/- 0.4, bpm/mm Hg

p < 0.05, n = 8), but not for lSNA in 2K1C rats. The results show that DnX normalized baseline sympathetic vasomotor activity to the lumbar and renal nerves, followed by a differential improvement in the arterial baroreceptor sensitivity. Whether the baroreceptor function sensitivity improvement induced by DnX is a cause or a consequence of BP reduction remains to be determined.
Keywords Renal nerve
Renal denervation
Sympathoexcitation
Baroreflex dysfunction
Renovascular hypertension
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor FAPESP [2013/13332-1, 2013/23741-6]
CAPES [23038.003092/2014-61, 0523/2014]
CNPq [472613/2013-8]
CNPq fellowships
CAPES-PNPD Postdoctoral Fellowships
Grant number FAPESP [2013/13332-1, 2013/23741-6]
CAPES [23038.003092/2014-61, 0523/2014]
CNPq [472613/2013-8]
Date 2017
Published in Autonomic Neuroscience-Basic & Clinical. Amsterdam, v. 208, p. 43-50, 2017.
ISSN 1566-0702 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 43-50
Origin http://dx.doi.org/10.1016/j.autneu.2017.06.002
Access rights Closed access
Type Article
Web of Science ID WOS:000423642600005
URI https://repositorio.unifesp.br/handle/11600/54024

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