High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males

High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males

Author Souza, Jorge Fernando Tavares de Autor UNIFESP Google Scholar
Dattilo, Murilo Autor UNIFESP Google Scholar
Mello, Marco Tulio de Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Antunes, Hanna Karen Moreira Autor UNIFESP Google Scholar
Abstract Introduction: Sleep deprivation can impair several physiological systems and recently, new evidence has pointed to the relationship between a lack of sleep and carbohydrate metabolism, consequently resulting in insulin resistance. To minimize this effect, High-Intensity Interval Training (HIIT) is emerging as a potential strategy. Objective: The aim of this study was to investigate the effects of HIIT on insulin resistance induced by sleep deprivation. Method: Eleven healthy male volunteers were recruited, aged 18-35 years, who declared taking 7-8 h sleep per night. All volunteers were submitted to four different conditions: a single night of regular sleep (RS condition), 24 h of total sleep deprivation (SD condition), HIIT training followed by regular sleep (HIIT+RS condition), and HIIT training followed by 24 h of total sleep deprivation (HIIT+SD condition). They performed six training sessions over 2 weeks and each session consisted of 8-12 x 60s intervals at 100% of peak power output. In each experimental condition, tests for glucose, insulin, Cortisol, free fatty acids, and insulin sensitivity, measured by oral glucose tolerance test (OGTT), were performed. Results: Sleep deprivation increased glycaemia and insulin levels, as well as the area under the curve. Furthermore, an increase in free fatty acids concentrations and basal metabolism was observed. There were no differences in the concentrations of Cortisol. However, HIIT before 24 h of sleep deprivation attenuated the increase of glucose, insulin, and free fatty acids. Conclusion: Twenty-four hours of sleep deprivation resulted in acute insulin resistance. However, HIIT is an effective strategy to minimize the deleterious effects promoted by this condition.
Keywords High-intensity interval training
Sleep deprivation
Insulin resistance
Glucose metabolism
Physical exercise
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2010-07005-0
CNPq: 4001129/2016-7
Date 2017
Published in Frontiers In Physiology. Lausanne, v. 8, p. -, 2017.
ISSN 1664-042X (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin https://dx.doi.org/10.3389/fphys.2017.00992
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000417269300001
URI https://repositorio.unifesp.br/handle/11600/54005

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