Unbalanced plasma TNF-alpha and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes

Unbalanced plasma TNF-alpha and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes

Author Oliveira, Arao Belitardo Autor UNIFESP Google Scholar
Lacerda Bachi, Andre Luis Google Scholar
Ribeiro, Reinaldo Teixeira Autor UNIFESP Google Scholar
Meho, Marco Tulio Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Prieto Peres, Mario Fernando Autor UNIFESP Google Scholar
Abstract Increased plasma pro-inflammatory and decreased anti-inflammatory cytokines have been implicated in physiological and behavioural aspects of mood- and pain-related disorders, including migraine. In this case-control study, we assessed mood scores, cardiorespiratory fitness (VO2peak), and plasma concentrations of TNF-alpha, IL-1 beta IL-6, IL-8, IL-10, and IL-12p70 interictally in women with episodic migraine with/without aura (ICHD-II), taking no preventive medicine, and in healthy women recruited from Sao Paulo Hospital and local community, respectively. Thirty-seven participants (mean +/- SD age = 34 +/- 10 and BMI = 26.5 +/- 4.9) were assessed. Groups (Control, n = 17

Migraine, n = 20) showed no differences in age, BMI, and VO2peak. Migraine patients showed higher tension (p = 0.019) and anxiety scores (p = 0.046), TNF-alpha (p < 0.01), and IL-12p70 (p = 0.01), while IL-6 (p < 0.01), IL-8 (p < 0.01), and IL-10 (p < 0.01) were decreased compared to control group. Multiple linear regression models showed that migraine was positively associated with TNF-alpha and IL-12p70, and negatively associated with IL-6, IL-8, and IL-10. Anxiety scores were positively associated with IL-12p70, and VO2peak was negatively associated with TNF-alpha. In conclusion, an exaggeratedly skewed cytokine profile, in particular the TNF-alpha and 12p70/IL-10 balance may be related to migraine pathomechanisms, and its psychiatric comorbidities and functional capacity. Additional studies are needed to confirm these results.
Keywords Immune system
Cytokines
Peak oxygen uptake
Anxiety
Chronic pain
Primary headaches
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Date 2017
Published in Journal Of Neuroimmunology. Amsterdam, v. 313, p. 138-144, 2017.
ISSN 0165-5728 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 138-144
Origin http://dx.doi.org/10.1016/j.jneuroim.2017.09.008
Access rights Closed access
Type Article
Web of Science ID WOS:000423006700022
URI https://repositorio.unifesp.br/handle/11600/53993

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