Sleep Duration and Quality as Related to Left Ventricular Structure and Function

Sleep Duration and Quality as Related to Left Ventricular Structure and Function

Author Lee, Jae-Hon Google Scholar
Park, Sung Keun Google Scholar
Ryoo, Jae-Hong Google Scholar
Oh, Chang-Mo Google Scholar
Kang, Jeong Gyu Google Scholar
Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Alfonsi, Jeffrey E. Google Scholar
Lee, Yena Google Scholar
Shin, Sun-Han Google Scholar
McIntyre, Roger S. Google Scholar
Jung, Ju Young Google Scholar
Abstract Objective Inadequate sleep is associated with increased risk of cardiovascular events; however, the associations between sleep duration or quality and cardiac function or structure are not well understood. This cross-sectional study was conducted to investigate to what extent sleep duration and quality are associated with left ventricular (LV) diastolic dysfunction or structural deterioration. Methods A total of 31,598 healthy Korean adults who received echocardiography and completed the Pittsburg Sleep Quality Index were enrolled in this study. Participants were stratified into three groups by self-reported sleep duration (i.e., <7, 7-9, >9 hours) and into two groups by subjective sleep quality. Sleep duration was also assessed as a continuous variable. The odds ratios for impaired LV diastolic function, increased relative wall thickness, and LV hypertrophy (LVH) were compared between groups using multivariable logistic regression analyses. Results After adjustment for confounding variables (e.g., age, smoking, body mass index), there was a statistically significant association between short sleep duration (<7 hours) and greater LVH (fully adjusted odds ratio = 1.32 [95% confidence interval {CI} = 1.02-1.73]). Short sleep duration was also significantly associated with greater LVH (0.87 per hour [95% CI = 0.78-0.98]) and increased relative wall thickness (0.92 [95% CI = 0.86-0.99]), but there was no significant association between sleep and LV diastolic function. Among individuals with normal sleep duration, poor quality of sleep was not associated with adverse cardiac measures. Conclusions These results indicate that short sleep duration (<7 hours) is associated with unfavorable LV structural characteristics. The association of insufficient sleep with adverse cardiovascular health outcomes may be mediated in part by adverse changes in cardiac structure and function.
Keywords hypertrophy
left ventricular function
remodeling
sleep duration
sleep quality
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor FAPESP, Brazil
Lundbeck, Canada
Lundbeck
JanssenOrtho
Shire
Purdue
AstraZeneca
Pfizer
Otsuka
Allergan
Stanley Medical Research Institute
Elli-Lilly
Johnson Johnson
Moksha8
Sunovion
Mitsubishi
Takeda
Forest
Bristol-Myers Squibb
Date 2018
Published in Psychosomatic Medicine. Philadelphia, v. 80, n. 1, p. 78-86, 2018.
ISSN 0033-3174 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 78-86
Origin http://dx.doi.org/10.1097/PSY.0000000000000528
Access rights Closed access
Type Article
Web of Science ID WOS:000419639100015
URI https://repositorio.unifesp.br/handle/11600/53936

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