Gluten related illnesses and severe mental disorders: a comprehensive review

Gluten related illnesses and severe mental disorders: a comprehensive review

Author Brietzke, Elisa Autor UNIFESP Google Scholar
Cerqueira, Raphael O. Autor UNIFESP Google Scholar
Mansur, Rodrigo B. Google Scholar
McIntyre, Roger S. Google Scholar
Abstract The putative role of gluten in the pathophysiology of severe mental illnesses remains uncertain and there is doubt about the possible benefit of gluten-free diets for individuals affected by psychosis and mood disorders. The objective of this review was to summarize the findings linking gluten related conditions to pathophysiological substrates implicated in schizophrenia and mood disorders and review the evidences of potential benefits of glute-free diets in these populations. A literature search was conducted within PubMed and Scielo databases including references from inception until March 1st 2017. The strategy search was to use the key words "gluten", "celiac disease", "wheat", "bipolar disorder", "mood disorders", "psychosis", "schizophrenia", "depression". In the review about the potential efficacy of gluten-free diets in severe mental illnesses, we included only studies with original data, including cross sectional and longitudinal studies and clinical trials. Book chapters, review articles and meta-analysis and republished data were excluded. Although the current available evidences suggest that people with celiac disease or gluten allergy could have a slightly higher risk of schizophrenia and mood disorders compared to the general population, the literature review reveals significant inaccuracies in the data. There is insufficient evidence to recommend gluten-free diets for populations with psychosis and mood disorders.
Keywords Gluten
Gluten-free diet
Bipolar disorder
Mood disorders
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Date 2018
Published in Neuroscience And Biobehavioral Reviews. Oxford, v. 84, p. 368-375, 2018.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 368-375
Access rights Closed access
Type Article
Web of Science ID WOS:000419419000031

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