Multiple sclerosis risk perception and acceptance for Brazilian patients

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dc.contributor.author Bichuetti, Denis Bernardi
dc.contributor.author Franco, Carolina Azze
dc.contributor.author Elias, Isaac
dc.contributor.author Mendonca, Andreia C. R.
dc.contributor.author Diniz Carvalho, Lorraine Fiama
dc.contributor.author Diniz, Denise Sisterolli
dc.contributor.author Tur, Carmen
dc.contributor.author Tintore, Mar
dc.contributor.author Lobato de Oliveira, Enedina Maria
dc.date.accessioned 2020-07-02T18:52:09Z
dc.date.available 2020-07-02T18:52:09Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1590/0004-282X20170167
dc.identifier.citation Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 76, n. 1, p. 6-12, 2018.
dc.identifier.issn 0004-282X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53910
dc.description.abstract The perception of multiple sclerosis (MS) severity and risk associated with therapies might influence shared decision making in different countries. We investigated the perception of MS severity and factors associated with risk acceptance in Brazil in 96 patients with relapsing-remitting MS using a standardized questionnaire and compared this with two European cohorts. Multiple sclerosis was perceived as a very severe disease and the risk of developing progressive multifocal leukoencephalopathy due to natalizumab was seen as moderate to high. Seventy-six percent considered a risk of 1:1,000, or higher, an impediment for natalizumab use. Older age was the only variable associated with higher risk acceptance and our patients showed a more conservative profile than German and Spanish patients. Our patients perceived MS severity and progressive multifocal leukoencephalopathy risk similarly to elsewhere, but their willingness to take risks was more conservative. This should be considered when discussing therapeutic options and it might have an impact on guideline adaptations. en
dc.format.extent 6-12
dc.language.iso eng
dc.publisher Assoc Arquivos Neuro- Psiquiatria
dc.relation.ispartof Arquivos De Neuro-Psiquiatria
dc.rights Acesso aberto
dc.subject multiple sclerosis en
dc.subject natalizumab en
dc.subject risk-taking en
dc.subject risk assessment en
dc.subject decision making en
dc.title Multiple sclerosis risk perception and acceptance for Brazilian patients en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Disciplina Neurol, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Goias, Fac Estacio Sa Goias, Ctr Referencia & Invest Esclerose Multipla, Goiania, Go, Brazil
dc.description.affiliation Univ Fed Goias, Ctr Referencia & Invest Esclerose Multipla, Goiania, Go, Brazil
dc.description.affiliation Univ Autonoma Barcelona, Hosp Univ ValldHebron, Ctr Catalonia, Dept Neurol Neuroimmunol & Multiple Sclerosis, Barcelona, Spain
dc.description.affiliation UCL, Inst Neurol, Dept Neuroinflammat, London, England
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Disciplina Neurol, Sao Paulo, SP, Brazil
dc.identifier.file WOS000422938800003.pdf
dc.identifier.doi 10.1590/0004-282X20170167
dc.description.source Web of Science
dc.identifier.wos WOS:000422938800003
dc.coverage Sao Paulo Sp
dc.citation.volume 76
dc.citation.issue 1



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