Purinergic system in psychiatric diseases

Purinergic system in psychiatric diseases

Author Cheffer, A. Google Scholar
Castillo, A. R. G. Google Scholar
Correa-Velloso, J. Google Scholar
Goncalves, M. C. B. Autor UNIFESP Google Scholar
Naaldijk, Y. Google Scholar
Nascimento, I. C. Google Scholar
Burnstock, G. Google Scholar
Ulrich, H. Google Scholar
Abstract Psychiatric disorders are debilitating diseases, affecting > 80 million people worldwide. There are no causal cures for psychiatric disorders and available therapies only treat the symptoms. The etiology of psychiatric disorders is unknown, although it has been speculated to be a combination of environmental, stress and genetic factors. One of the neurotransmitter systems implicated in the biology of psychiatric disorders is the purinergic system. In this review, we performed a comprehensive search of the literature about the role and function of the purinergic system in the development and predisposition to psychiatric disorders, with a focus on depression, schizophrenia, bipolar disorder, autism, anxiety and attention deficit/hyperactivity disorder. We also describe how therapeutics used for psychiatric disorders act on the purinergic system.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation, FAPESP) [2012/50880-4]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FAPESP [2013/02293-5, 2015/18730-0, 2015/14343-2]
Grant number FAPESP [2012/50880-4]
FAPESP [2013/02293-5, 2015/18730-0, 2015/14343-2]
Date 2018
Published in Molecular Psychiatry. London, v. 23, n. 1, p. 94-106, 2018.
ISSN 1359-4184 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 94-106
Origin http://dx.doi.org/10.1038/mp.2017.188
Access rights Closed access
Type Article
Web of Science ID WOS:000423441000012
URI https://repositorio.unifesp.br/handle/11600/53895

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