Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease

Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease

Author de Oliveira, Fabricio Ferreira Autor UNIFESP Google Scholar
Pereira, Fernando Vieira Autor UNIFESP Google Scholar
Kamikado Pivi, Glaucia Akiko Autor UNIFESP Google Scholar
Smith, Marilia Cardoso Autor UNIFESP Google Scholar
Ferreira Bertolucci, Paulo Henrique Autor UNIFESP Google Scholar
Abstract Background: Illiteracy, high cerebrovascular risk and copies of APOE-E4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year.Methods: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL).Results: For 191 patients, mean age at AD onset was 73.266.4 years-old, earlier for APOE-E4/E4 carriers (p = 0.0039). For women, higher BMI led to improvements in CDR-SOB ( = -0.091

p = 0.037) and MMSE ( = 0.126

p = 0.017) scores, while increased creatinine clearance was associated with improvements in ADL ( = 0.028

p = 0.012) and MMSE ( = 0.043

p = 0.039) scores and higher schooling led to faster worsening of IADL ( = -0.195

p = 0.022) scores. No variables impacted cognitive or functional decline for men, whereas copies of APOE-E4 and the CHD risk had no significant effects whatsoever.Conclusions: Higher BMI and creatinine clearance are protective regarding cognitive and functional decline for women, whereas higher cognitive reserve may lead to faster decline in instrumental functionality. APOE haplotypes affected the age at AD onset, but not cognitive or functional decline.
Keywords Activities of daily living
Alzheimer disease
cognition
educational status
risk factors
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor CAPES - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [1067/10]
FAPESP - The State of Sao Paulo Research Foundation [2015/10109-5]
Grant number CAPES [1067/10]
FAPESP [2015/10109-5]
Date 2018
Published in International Journal Of Neuroscience. Abingdon, v. 128, n. 5, p. 472-476, 2018.
ISSN 0020-7454 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 472-476
Origin http://dx.doi.org/10.1080/00207454.2017.1396986
Access rights Closed access
Type Article
Web of Science ID WOS:000425403000012
URI https://repositorio.unifesp.br/handle/11600/53859

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