Prostate cancer proteomics: clinically useful protein biomarkers and future perspectives

Prostate cancer proteomics: clinically useful protein biomarkers and future perspectives

Author Intasqui, Paula Autor UNIFESP Google Scholar
Bertolla, Ricardo P. Autor UNIFESP Google Scholar
Sadi, Marcus Vinicius Autor UNIFESP Google Scholar
Abstract Introduction: Although prostate cancer constitutes one of the most important, death-related diseases in the male population, there is still a need for identification of sensitive biomarkers that could precociously detect the disease and differentiate aggressive from indolent cancers, in order to decrease overtreatment. Proteomics research has improved understanding on mechanisms underlying tumorigenesis, cancer cells migration and invasion potential, and castration resistance. This review has focused on proteomic studies of prostate cancer published in the recent years, with a special emphasis on determination of biomarkers for cancer progression and diagnosis. Areas covered: Shotgun and targeted-proteomic studies of prostate cancer in different matrices are reviewed, i.e., prostate tissue, prostate cell lines, blood (serum and plasma), urine, seminal plasma, and exosomes. The most important biomarkers for cancer diagnosis and aggressiveness characterization are highlighted. Expert commentary: In general, results demonstrate alteration in cell cycle control, DNA repair, proteasomal degradation, and metabolic activity. However, these studies suffer from low reproducibility due to heterogeneity of the cancer itself, as well as to techniques utilized for protein identification/quantification. Downstream confirmatory studies in separate cohorts are warranted in order to demonstrate accuracy of these results.
Keywords Biomarkers
diagnosis
prognosis
proteomics
prostatic neoplasms
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Sao Paulo Research Foundation (FAPESP) [2014/11493-0]
National Council for Scientific and Technological Development (CNPq) [306616/2013-0]
Grant number FAPESP [2014/11493-0]
CNPq [306616/2013-0]
Date 2018
Published in Expert Review Of Proteomics. Abingdon, v. 15, n. 1, p. 65-79, 2018.
ISSN 1478-9450 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 65-79
Origin http://dx.doi.org/10.1080/14789450.2018.1417846
Access rights Closed access
Type Article
Web of Science ID WOS:000425750300006
URI https://repositorio.unifesp.br/handle/11600/53858

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