Chronic Obstructive Pulmonary Disease Exacerbations Are Influenced by Gastroesophageal Reflux Disease

Chronic Obstructive Pulmonary Disease Exacerbations Are Influenced by Gastroesophageal Reflux Disease

Author Bigatao, Amilcar M. Autor UNIFESP Google Scholar
Herbella, Fernando A. M. Autor UNIFESP Google Scholar
Del Grande, Leonardo M. Autor UNIFESP Google Scholar
Nascimento, Oliver A. Autor UNIFESP Google Scholar
Jardim, Jose R. Autor UNIFESP Google Scholar
Patti, Marco G. Google Scholar
Abstract Gastroesophageal reflux disease (GERD) is associated with different pulmonary diseases, including chronic obstructive pulmonary disease (COPD). Whether GERD is contributory to COPD severity remains unclear. This study aims to evaluate the contribution of GERD to the clinical manifestation of COPD based on ventilatory parameters and yearly clinical exacerbations. We studied 48 patients (56% females, age 66 years) with COPD. All patients underwent highresolution manometry and esophageal pH monitoring. The patients were separated into two groups according to the presence of GERD. GERD was present in 21 (44%) patients. GERD 1 and GERD - groups did not differ in regard to gender, age, and body mass index. Pulmonary parameters were not different in the absence or presence of GERD. The number of yearly exacerbations was higher in patients GERD1. The severity of GERD (as measured by DeMeester score) correlated with the number of exacerbations. Our results show the following: 1) GERD does not influence pulmonary parameters and 2) GERD is associated with a higher number of annual clinical exacerbations. We believe GERD must be objectively tested in patients with COPD because the prevalence of GERD in these patients is underestimated when only symptoms are considered. GERD treatment might decrease the frequency of episodes of exacerbation.
xmlui.dri2xhtml.METS-1.0.item-coverage Cumming
Language English
Date 2018
Published in American Surgeon. Cumming, v. 84, n. 1, p. 51-55, 2018.
ISSN 0003-1348 (Sherpa/Romeo, impact factor)
Publisher Southeastern Surgical Congress
Extent 51-55
Origin https://www.ingentaconnect.com/content/sesc/tas/2018/00000084/00000001/art00022
Access rights Closed access
Type Article
Web of Science ID WOS:000425926200022
URI https://repositorio.unifesp.br/handle/11600/53850

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