Concentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influence

Concentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influence

Author Torres, Sueli M. P. S. Autor UNIFESP Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Simoes, Ricardo S. Autor UNIFESP Google Scholar
Baracat, Edmund C. Autor UNIFESP Google Scholar
Simoes, Manuel de J. Autor UNIFESP Google Scholar
Fuchs, Luiz F. P. Autor UNIFESP Google Scholar
Soares-, Jose Maria, Jr. Autor UNIFESP Google Scholar
Gomes, Regina Celia T. Autor UNIFESP Google Scholar
Abstract It was to evaluate the concentration of sulfate glycosaminoglycans (GAG) in mammary tissue of the young and adult female rats and ovariectomized females rats after hormonal stimulation. For this purpose, 60 female rats were divided into six groups with 10 animals/each: nonovariectomized groups: G1 (5 months), and G2 (15 months) and ovariectomized groups: OG (vehicle)

EG: (estradiol, 7 days of treatment), PG (progesterone acetate, 23 days of treatment) and EPG: (estradiol (7 days of treatment) and next progesterone acetate (23 days of treatment). Twenty-four hours after the last treatment, all animals were euthanized, the mammary tissue removed, processed for biochemical evaluation and quantification of the GAG. The comparison between groups showed that the concentration dermatan sulfate (DS) G1 was lower compared to G2, OG, EG (p < .05) and G2 was lower compared to OG (p < .05), and OG was higher compared to EG, GP, EPG (p < .05)

and heparan sulfate (HS) G1 was higher compared to G2 (p < .05), and G2 was higher compared to OG, EP, PG and EPG (p < .05). These changes in the extracellular matrix might explain, at least in part, hormonal influence about sulfated glycosaminoglycans in response to physiological state/age, and in response to hormonal treatment in the mammary tissues.
Keywords Mammary tissue
sulfated glycosaminoglycans
estradiol
progesterone
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Date 2018
Published in Gynecological Endocrinology. Abingdon, v. 34, n. 1, p. 64-68, 2018.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 64-68
Origin http://dx.doi.org/10.1080/09513590.2017.1336218
Access rights Closed access
Type Article
Web of Science ID WOS:000428120800015
URI https://repositorio.unifesp.br/handle/11600/53812

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