HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort

HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort

Author de Freitas Campos Juca, Patricia Chaves Google Scholar
Correa, Stephany Google Scholar
Vignal, Giselle Maria Google Scholar
de Souza Accioly, Maria Theresa Google Scholar
Silva Lustosa, Suzana Angelica Autor UNIFESP Google Scholar
Abdelhay, Eliana Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Abstract Background: Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be easily applied in routine laboratory work. An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary tumor. Hepatocyte nuclear factor 4 alpha (HNF4A) has been suggested as a potential marker in these cases. The aim of this study was to analyze the expression of HNF4A, estrogen receptor (ER), progesterone receptor (PR) and gross cystic disease fluid protein 15 (GCDFP-15) in a Brazilian cohort. Methods: We performed immunohistochemistry analysis of HNF4A, ER, PR and GCDFP-15 in 126 patients divided into three cohorts: primary breast cancer, primary gastric cancer and both types of tumors. Results: Our data confirmed the sensitivity and specificity of the HNF4A marker compared to other currently used clinical markers. Conclusion: HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity.
Keywords HNF4A
Biomarker
Gastric cancer
Breast cancer
Metastasis
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor FAPERJ
Grant number FAPERJ: E26/110.664/2012
Date 2017
Published in Diagnostic Pathology. London, v. 12, p. -, 2017.
ISSN 1746-1596 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent -
Origin http://dx.doi.org/10.1186/s13000-017-0635-2
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000402635400001
URI https://repositorio.unifesp.br/handle/11600/53669

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