Pathophysiology of Gastroesophageal Reflux Disease

Pathophysiology of Gastroesophageal Reflux Disease

Author Menezes, Mariano A. Google Scholar
Herbella, Fernando A. M. Autor UNIFESP Google Scholar
Abstract Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaphragmatic pressure gradient. Antireflux mechanisms include the lower esophageal sphincter and abdominal esophagus, the diaphragm, the angle of His, the Gubaroff valve, and the phrenoesophageal membrane. Protective mechanisms include esophageal motility, saliva production, and epithelial protection. Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases).
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2017
Published in World Journal Of Surgery. New York, v. 41, n. 7, p. 1666-1671, 2017.
ISSN 0364-2313 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1666-1671
Type Article
Web of Science ID WOS:000403056400002

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