The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

Author Ribeiro de Oliveira, Teresinha Regina Autor UNIFESP Google Scholar
de Oliveira, Geraldo Ferreira Google Scholar
Simoes, Ricardo Santos Autor UNIFESP Google Scholar
Tikazawa, Eduardo Hiroshi Google Scholar
Monteiro, Hugo Pequeno Autor UNIFESP Google Scholar
Fagundes, Djalma Jose Autor UNIFESP Google Scholar
Taha, Murched Omar Autor UNIFESP Google Scholar
Abstract Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.)

(IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.)

(IRPTX): PTX + ischemia (30min.) + reperfusion (60 min.)

(IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.)

(IPC-IR-PTX): 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R. Results: The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower. Conclusion: Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together.
Keywords Ischemic Preconditioning
Pentoxifylline
Ischemia
Reperfusion Injury
Intestines
Rats
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor UFGD, Ministerio da Educacao do Brasil
Grant number UFGD, Ministerio da Educacao do Brasil
Date 2017
Published in Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 559-567, 2017.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 559-567
Origin http://dx.doi.org/10.1590/s0102-865020170070000007
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000407368300007
SciELO ID S0102-86502017000700559 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/53550

Show full item record




File

Name: S0102-86502017000700559.pdf
Size: 631.0Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account