Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?]

Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?]

Author Soares Alves, Ana Karina Autor UNIFESP Google Scholar
Lanzoni, Valeria Autor UNIFESP Google Scholar
Fuziy, Rogerio Aoki Autor UNIFESP Google Scholar
Monteiro Moura Franco, Rita Maria Aparecida Autor UNIFESP Google Scholar
Maeda, Carlos Toshinori Autor UNIFESP Google Scholar
Lopes Filho, Gaspar de Jesus Autor UNIFESP Google Scholar
Linhares, Marcelo Moura Autor UNIFESP Google Scholar
Abstract Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then similar to 10(6) mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05). Conclusions: Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly.
Keywords Mesenchymal Stem Cell Transplantation
Liver Regeneration
Hepatectomy
Cell-and Tissue-Based Therapy
Rats
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Date 2017
Published in Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 515-522, 2017.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 515-522
Origin http://dx.doi.org/10.1590/s0102-865020170070000002
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000407368300002
SciELO ID S0102-86502017000700515 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/53549

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