Zika Virus Outbreak - Should assisted reproduction patients avoid pregnancy?

Zika Virus Outbreak - Should assisted reproduction patients avoid pregnancy?

Author Borges, Edson, Jr. Google Scholar
de Almeida Ferreira Braga, Daniela Paes Autor UNIFESP Google Scholar
Zanetti, Bianca Ferrarini Google Scholar
Setti, Amanda Souza Google Scholar
Provenza, Rodrigo Rosa Google Scholar
Iaconelli, Assumpto, Jr. Google Scholar
Abstract Objective: To discuss the requirement from the National Health Surveillance Agency(ANVISA), for assisted reproduction treatment patients to undergo laboratory tests for ZIKV detection, and if the public health authorities and government leaders' recommendations to women simply avoid pregnancy is prudent. Methods: This study was performed in a universityaffiliated in vitro fertilization center in Brazil. We present a critical discussion on the risk of microcephaly due to ZIKV infection and the prevalence of other harmful pathogens to vulnerable pregnant women and infants. We assessed, 954 patients undergoing intracytoplasmic sperm injection cycles(ICSI), between April and November of 2016, concerning the results of ZIKV test, according to different regions in Brazil. Results: Patients undergoing ICSI cycles were split into groups, according to their region of origin: 28(3.0%) were from the North, 27(2.8%) were from the Northeast, 40(4.2%) were from the Midwest, 830(87.2%) were from the Southeast, and 29(3.0%) were from the South. Concerning the diagnosis, 112 samples had a positive or inconclusive result for ZIKV, by chromatography immunoassay. These samples were re-analyzed by ELISA and no result was positive. All positive results were from the Southeast region and none from the Northeast or Midwest regions, which are considered endemic regions. Conclusion: ZIKV test before the onset of assisted reproduction treatments does not rule out the risk of the infection during pregnancy. In addition, although ZIKV infection risk is extremely high, the microcephaly risk due to ZIKV is not higher than the risk of miscarriage and birth defects due to other recognized pathogens.
Keywords Zika virus
pregnancy
miscarriage
microcephaly
birth defects
xmlui.dri2xhtml.METS-1.0.item-coverage Ribeirao
Language English
Date 2017
Published in Jornal Brasileiro De Reproducao Assistida. Ribeirao, v. 21, n. 3, p. 208-211, 2017.
ISSN 1517-5693 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Reproducao Assistida-Sbra
Extent 208-211
Origin http://dx.doi.org/10.5935/1518-0557.20170040
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000411259400007
URI https://repositorio.unifesp.br/handle/11600/53514

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