The predictive value of serum concentrations of anti-Mullerian hormone for oocyte quality, fertilization, and implantation

The predictive value of serum concentrations of anti-Mullerian hormone for oocyte quality, fertilization, and implantation

Author Borges, Edson Google Scholar
Braga, Daniela P. A. F. Autor UNIFESP Google Scholar
Setti, Amanda Google Scholar
Figueira, Rita de Cassia Google Scholar
Iaconelli, Assumpto, Jr. Google Scholar
Abstract Objective: This study aimed to identify a possible correlation between serum levels of anti-.Mullerian hormone (AMH) and oocyte quality, embryo developmental competence, and implantation potential. Methods: 4488 oocytes obtained from 408 patients undergoing ICSI cycles were evaluated. Oocyte dimorphisms, embryo quality on days two and three, blastocyst formation competence, fertilization rates, implantation rates, and pregnancy rates were correlated with serum levels of AMH using Pearson's correlation coefficient and regression analysis. Results: A positive correlation was observed between serum levels of AMH and number of retrieved oocytes (CC: 0.600, p<0.001), fertilization rate (CC: 0.595, p=0.048), and number of obtained embryos (CC: 0.495, p<0.001). AMH did not affect the quality of cleavage stage embryos or the chance of blastocyst formation. However, AMH levels affected oocyte quality (OR: 0.75, CI 0.44-.0.96, p<0.001), and implantation (CC: 0,116, p=0.031) and pregnancy (OR: 1.22, CI: 1.03-.1.53, p<0.001) rates. Conclusion: Serum levels of AMH are a useful predictor of ovarian response to COS, oocyte quality, and fertilization. However, AMH levels may also compromise clinical outcomes

lower AMH levels did not impair embryo development.
Keywords Oocyte
blastocyst
embryo implantation
pregnancy
COS cells
anti-Mullerian hormone
xmlui.dri2xhtml.METS-1.0.item-coverage Ribeirao
Language English
Date 2017
Published in Jornal Brasileiro De Reproducao Assistida. Ribeirao, v. 21, n. 3, p. 176-182, 2017.
ISSN 1517-5693 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Reproducao Assistida-Sbra
Extent 176-182
Origin http://dx.doi.org/10.5935/1518-0557.20170035
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000411259400003
URI https://repositorio.unifesp.br/handle/11600/53513

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