Futura study: evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitis

Futura study: evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitis

Alternative title Estudo futura: avaliação da eficácia e segurança do fumarato de rupatadina no tratamento da rinite alérgica persistente
Author Mion, Olavo de Godoy Google Scholar
Campos, Regis A. Google Scholar
Antila, Martti Google Scholar
Rapoport, Priscila Bogar Google Scholar
Rosario Filho, Nelson Augusto Google Scholar
Mello Júnior, João Ferreira de Google Scholar
Guimarães, Roberto Eustáquio Santos Google Scholar
Mocellin, Marcos Google Scholar
Di Gesu, Giovanni Google Scholar
Solé, Dirceu Autor UNIFESP Google Scholar
Wexler, Luc Autor UNIFESP Google Scholar
Mello, João Ferreira de Autor UNIFESP Google Scholar
Castro, Fábio Fernandes Morato Google Scholar
Chavarria, Maria Letícia Google Scholar
Institution Universidade de São Paulo (USP)
Yale University School of Medicine Allergy Department
Federal University of Bahia Medical School
ASBAI
Ophthalmology Hospital Department ENT
Medical School
Federal University of Paraná
University of São Paulo Medical School
Federal University of Minas Gerais Medical School Department of Otorhinolaryngology and Ophthalmology
Federal University of Paraná ENT Department
Santa Casa de Porto Alegre Hospital Santo Antônio Children Hospital Allergy Department
Universidade Federal de São Paulo (UNIFESP)
State Public Servant Hospital Allergy Department
UFG
Abstract Allergic rhinitis affects 10-30% of the population, negatively impacting one's quality of life and productivity. It has been associated with sinusitis, otitis media, sleep disorders, and asthma. Rupatadine is a second generation antihistamine with increased affinity to histamine receptor H1; it is also a potent PAF (platelet-activating factor) antagonist. It starts acting quite quickly, offers long lasting effect, and reduces the chronic effects of rhinitis. AIM: this study aims to assess the efficacy and safety of rupatadine in the treatment of persistent allergic rhinitis. MATERIALS AND METHOD: this is a multi-centric open prospective study. This study included 241 patients from 13 centers in Brazil and was held between October of 2004 and August of 2005. Signs and symptoms of rhinitis and tolerance to medication were analyzed after one and two weeks of treatment. RESULTS: reduction on general scores from 8.65 to 3.21 on week 2 (p<0.001). All signs and symptoms improved significantly in the first day of treatment (p<0.001), except for nasal congestion and secretion, which improved from the second day of treatment (p<0.001). Adverse events occurred in 19.9% of the cases, 27.7% on week 1. CONCLUSION: rupatadine effectively controls persistent allergic rhinitis; it is safe and presents low incidence of side effects.

A rinite alérgica acomete 10 a 30% da população, interferindo na qualidade de vida e na capacidade produtiva. Está associada à sinusite, otite, roncopatias e asma. A Rupatadina é um anti-histamínico de segunda geração, com elevada afinidade ao receptor histamínico H1 e potente inibição do fator ativador plaquetário (PAF). Tem rápido início de ação, longa duração e reduz os efeitos crônicos da rinite. OBJETIVO: Avaliar a eficácia e segurança da rupatadina no tratamento da rinite alérgica persistente. MATERIAL E MÉTODO: Estudo multicêntrico, aberto, prospectivo. Foram selecionados 241 pacientes em 13 centros no Brasil durante o período de outubro de 2004 a agosto de 2005. Foram analisados os sinais e sintomas da rinite e a tolerabilidade após 1 e 2 semanas. RESULTADOS: Redução do escore geral de 8,65 para 3,21 na semana 2 (p<0,001). Todos os sinais e sintomas melhoraram significativamente, e no primeiro dia de tratamento (p<0,001), com exceção da obstrução e secreção nasal, a partir do segundo dia (P<0,001). A frequência de eventos adversos foi 19,9%, sendo 27,7% na 1ª semana. CONCLUSÕES: A rupatadina é eficaz no controle da rinite alérgica persistente, é segura e apresenta baixos índices de efeitos colaterais.
Keywords perennial allergic rhinitis
therapy
rinite alérgica perene
terapia
Language English
Date 2009-10-01
Published in Brazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 75, n. 5, p. 673-679, 2009.
ISSN 1808-8694 (Sherpa/Romeo)
Publisher Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Extent 673-679
Origin http://dx.doi.org/10.1590/S1808-86942009000500011
Access rights Open access Open Access
Type Article
SciELO ID S1808-86942009000500011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/5294

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