Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway

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dc.contributor.author Kanchanatawan, Buranee
dc.contributor.author Sirivichayakul, Sunee
dc.contributor.author Thika, Supaksorn
dc.contributor.author Ruxrungtham, Kiat
dc.contributor.author Carvalho, Andre F.
dc.contributor.author Geffard, Michel
dc.contributor.author Anderson, George
dc.contributor.author Noto, Cristiano [UNIFESP]
dc.contributor.author Ivanova, Rada
dc.contributor.author Maes, Michael
dc.date.accessioned 2019-08-19T11:50:17Z
dc.date.available 2019-08-19T11:50:17Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1007/s11011-017-9982-7
dc.identifier.citation Metabolic Brain Disease. New York, v. 32, n. 4, p. 1003-1016, 2017.
dc.identifier.issn 0885-7490
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51506
dc.description.abstract To investigate the frequency of physio-somatic symptoms (PS) symptoms in schizophrenia and their relation to positive, negative and affective symptoms en
dc.description.abstract neurocognitive deficits and impairments in the tryptophan catabolite (TRYCAT) pathway. Eighty four patients with schizophrenia and 40 healthy controls were assessed using the 12 item Fibromyalgia and Chronic Fatigue Syndrome Rating scale (FF) and scales for negative and positive symptoms, depression and anxiety. Cognitive functioning was tested using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Other assessments included: immunoglobulin (Ig)A and IgM responses to tryptophan catabolites (TRYCATs), namely quinolinic (QA), 3-OH-kynurenine (3HK), picolinic (PA), xanthurenic (XA) and kynurenic acid (KA) and anthranilic acid (AA). More than 50% of the patients studied had elevated levels of physio-somatic (PS) symptoms, significantly co-occurring with depression and anxiety, but not with negative or positive symptoms. PS symptoms were significantly associated with IgA/IgM responses to TRYCATs, including increased IgA responses to 3 HK, PA and XA, and lowered IgA to QA and AA. Fatigue, muscle pain and tension, autonomic and cognitive symptoms and a flu-like malaise were strongly associated with cognitive impairments in spatial planning and working memory, paired associative learning, visual sustained attention and attention set shifting. PS symptoms in schizophrenia aggregate with depression and anxiety symptoms and may be driven by TRYCAT patterning of IgA/IgM-responses, with IgA indicating mucosal-mediated changes and IgM indicating regulatory functions. As such, the patterning of IgA/IgM responses to TRYCATs may indicate differential TRYCATs regulation of neuronal and glia activity that act to regulate PS signalling in schizophrenia. en
dc.description.sponsorship Asahi Glass Foundation
dc.description.sponsorship Chulalongkorn University Centenary Academic Development Project
dc.description.sponsorship IDRPHT
dc.description.sponsorship Gemac, France
dc.format.extent 1003-1016
dc.language.iso eng
dc.publisher Springer/Plenum Publishers
dc.rights Acesso restrito
dc.subject Schizophrenia en
dc.subject Depression en
dc.subject Chronic fatigue en
dc.subject Neurocognitive impairments en
dc.subject immune en
dc.subject Cytokines en
dc.subject Leaky gut en
dc.subject Inflammation en
dc.title Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway en
dc.type Artigo
dc.description.affiliation Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand
dc.description.affiliation Chulalongkorn Univ, Fac Med, Bangkok, Thailand
dc.description.affiliation Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, CE, Brazil
dc.description.affiliation Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, CE, Brazil
dc.description.affiliation IDRPHT, Res Dept, Talence, France
dc.description.affiliation GEMAC, St Jean Dillac, France
dc.description.affiliation CRC Sotland & London, Eccleston Sq, London, England
dc.description.affiliation Univ Fed São Paulo UNIFESP, Dept Psychiat, Rua Pedro de Toledo 669,3 Andar, BR-04039032 São Paulo, SP, Brazil
dc.description.affiliation Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria
dc.description.affiliation Univ Estadual Londrina, Dept Psychiat, Fac Med, Londrina, Brazil
dc.description.affiliation Revitalis, Waalre, Netherlands
dc.description.affiliation Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia
dc.description.affiliationUnifesp Univ Fed São Paulo UNIFESP, Dept Psychiat, Rua Pedro de Toledo 669,3 Andar, BR-04039032 São Paulo, SP, Brazil
dc.identifier.doi 10.1007/s11011-017-9982-7
dc.description.source Web of Science
dc.identifier.wos WOS:000405327200009



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