Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats

Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats

Author Cardoso, Fabrizio dos Santos Google Scholar
Franca, Erivelton Fernandes Google Scholar
Serra, Fernando Tadeu Google Scholar
Victorino, Angelica Begatti Autor UNIFESP Google Scholar
de Almeida, Alexandre Aparecido Autor UNIFESP Google Scholar
Fernandes, Jansen Autor UNIFESP Google Scholar
Cabral, Francisco Romero Google Scholar
Venancio, Daniel Paulino Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
da Silva, Sergio Gomes Google Scholar
Abstract Aging is often accompanied by cognitive decline, memory impairment, and an increased susceptibility to neurodegenerative disorders. Although the physiological processes of aging are not fully understood, these age-related changes have been interpreted by means of various cellular and molecular theories. Among these theories, alterations in the intracellular signaling pathways associated with cell growth, proliferation, and survival have been highlighted. Based on these observations and on recent evidence showing the beneficial effects of exercise on cognitive function in the elderly, we investigated the cell signaling pathways in the hippocampal formation of middle-aged rats (18months old) submitted to treadmill exercise over 10 days. To do this, we evaluated the hippocampal activation of intracellular signaling proteins linked to cell growth, proliferation, and survival, such as Akt, mTOR, p70S6K, ERK, CREB, and p38. We also explored the cognitive performance (inhibitory avoidance) of middle-aged rats. It was found that physical exercise reduces ERK and p38 activation in the hippocampal formation of aged rats, when compared to the control group. The hippocampal activation and expression of Akt, mTOR, p70S6K, and CREB were not statistically different between the groups. It was also observed that aged rats from the exercise group exhibited better cognitive performance in the inhibitory avoidance task (aversive memory) than aged rats from the control group. Our results indicate that physical exercise reduces intracellular signaling pathways linked to inflammation and cell death (i.e., ERK and p38) and improves memory in middle-aged rats.
Keywords aging
physical exercise
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo ao Ensino e Pesquisa (FAEP)
Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 14/00035-1
Date 2017
Published in Hippocampus. Hoboken, v. 27, n. 8, p. 899-905, 2017.
ISSN 1050-9631 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 899-905
Access rights Closed access
Type Article
Web of Science ID WOS:000405552500007

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