Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in paediatric sickle cell disease

Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in paediatric sickle cell disease

Author Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Smith, Olufemi Samuel Google Scholar
Adekile, Adekunle D. Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Abstract Background. Alteration in the concentration of inflammatory cytokines may contribute to pathogenesis in sickle cell anaemia (SCA). Vitamin D may suppress pro-inflammatory cytokines and enhance anti-inflammatory cytokines. Objective: To compare steady state levels of pro-and anti-inflammatory cytokines of Nigerian SCA children with age-and sex-matched healthy controls, and determine the relationship with 25-hydroxyvitamin-D (25-OHD). Effects of three months of vitamin D supplementation on cytokines of SCA children with suboptimal 25-OHD were also evaluated. Methods: Serum 25-OHD, IL-113, 2, 6, 8, 11, 12, 13, 17, 18 of 95 SCA children and 75 matched controls were determined using HPLC. The 12 SCA children with suboptimal 25-OHD received 2000 IU of vitamin D daily for 3 months, and their post supplementation cytokines and 25-OHD levels were compared with the baseline values. Results: IL-2, 6, 8, 12, 17 and 18 were higher in SCA children than the controls (p <= 0.001), but no significant variation in IL-11 and 13 (p = 0.131 and 0.057 respectively). Patients with suboptimal serum 25-OHD had higher IL-6, 8 and 18 (p = 0.003, 0.010 and 0.002 respectively) and lower levels of IL-11 (p = 0.005). Significant positive treatment effects were observed: post-supplementation, serum 25-OHD increased by 23.3 ng/mL, p < 0.001

proinflammatory cytokines IL-2, 6, 8, 17 and 18 (p < 0.001) were reduced and anti-inflammatory cytokine IL-11 was increased, p < 0.001. Conclusions: Suboptimal 250HD is associated with enhanced levels of pro-inflammatory markers in children with SCA. Three months of daily vitamin D supplementation reversed the trend. Hence

Vitamin D supplementation may reduce the inflammatory milieu and serve as an anti-inflammatory agent in the management of SCA.
Keywords Cytokines
Paediatric
Sickle cell disease
Supplementation
25-Hydroxyvitamin D
Language English
Sponsor Brazil National Council for Research (CNPq)
CNPq - Africa Countries Collaborative Postgraduate Research Training in Hematology
CAPES/SUS (Coordination of Improvement of Higher Level Personnel)
Date 2017
Published in Cytokine. London, v. 96, p. 87-93, 2017.
ISSN 1043-4666 (Sherpa/Romeo, impact factor)
Publisher Academic Press Ltd- Elsevier Science Ltd
Extent 87-93
Origin http://dx.doi.org/10.1016/j.cyto.2017.03.010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000405042800012
URI http://repositorio.unifesp.br/handle/11600/51496

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