NO control of mitochondrial function in normal and transformed cells

NO control of mitochondrial function in normal and transformed cells

Author Tengan, Celia H. Autor UNIFESP Google Scholar
Moraes, Carlos T. Google Scholar
Abstract Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. (C) 2017 Elsevier B.V. All rights reserved.
Keywords Nitric oxide
Nitric oxide synthase
Mitochondria
Cancer
Respiratory chain
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
National Institutes of Health (NIH)
Muscular Dystrophy Association
Grant number FAPESP: 2007/03134-9
NIH: 1R01NS079965
NIH: 1R01AG036871
NIH: 5R01EY010804
NIH: 1R21ES025673
MDA: 294407
Date 2017
Published in Biochimica Et Biophysica Acta-Bioenergetics. Amsterdam, v. 1858, n. 8, p. 573-581, 2017.
ISSN 0005-2728 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 573-581
Origin http://dx.doi.org/10.1016/j.bbabio.2017.02.009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000405763800003
URI http://repositorio.unifesp.br/handle/11600/51487

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account