Evaluating Structural Progression of Retinitis Pigmentosa After Cataract Surgery

Evaluating Structural Progression of Retinitis Pigmentosa After Cataract Surgery

Author De Rojas, Joaquin O. Google Scholar
Schuerch, Kaspar Google Scholar
Mathews, Priya M. Google Scholar
Cabral, Thiago Autor UNIFESP Google Scholar
Hazan, Albert Google Scholar
Sparrow, Janet Google Scholar
Tsang, Stephen H. Google Scholar
Suh, Leejee H. Google Scholar
Abstract PURPOSE: To determine whether cataract surgery accelerates disease progression in retinitis pigmentosa (RP). DESIGN: Retrospective cohort study. METHODS: Seventy eyes of 40 patients with RP were categorized as having had phacoemulsification with intraocular lens implantation vs no cataract surgery at a single tertiary-level institution. Spectral-domain optical coherence tomography (SDOCT) was used to measure the ellipsoid zone (EZ) width, which has been demonstrated to be a reliable marker of RP severity, at baseline and throughout follow-up (median 768 days). RP progression was calculated as the loss of EZ width over time for all patients. Additional postoperative data were collected for the cataract surgery group, including preoperative and postoperative best-corrected visual acuity, incidence of macular edema, posterior capsular opacification, epiretinal membrane, and intraocular lens subluxation. RESULTS: Multivariable analysis including age, baseline EZ width, mode of inheritance, and cataract surgery status showed that there was no significant difference in RP progression between the cataract surgery and control groups (P = .23). Mode of inheritance was associated with RP progression, with autosomal recessive RP progressing at 148 mu m/year and autosomal dominant RP progressing at 91 mu m/year (P = .003). Visual acuity improved in almost all eyes that underwent surgery (17/19, 89%) and remained stable in remaining eyes (2/19,11%).There was a high incidence of postsurgical posterior capsular opacification (18/19, 95%). There were no serious complications, such as lens subluxation or endophthalmitis. CONCLUSIONS: Our findings suggest that cataract surgery is a safe and effective means of improving visual acuity in RP patients and that it does not seem to be associated with faster disease progression as measured using SDOCT. (C) 117-123. 2017 Elsevier Inc. All rights reserved.
Language English
Sponsor National Institute of Health (NIH), New York, NY
National Cancer Institute Core
Research to Prevent Blindness (RPB) Physician-Scientist Award
RPB, New York, New York, USA
ICO-Retina Research Foundation Helmerich Fellowships - Retina Research Foundation
ICOFoundation (International Council of Ophthalmology)
Tistou and Charlotte Kerstan Foundation
Schneeweiss Stem Cell Fund, New York State
Foundation Fighting Blindness New York Regional Research Center Grant
Gebroe Family Foundation
Grant number NIH: 5P30EY019007
NIH: R01EY018213
NIH: R01EY024698
NIH: 1R01EY026682
NIH: R21A0050437
National Cancer Institute Core: 5P30CA013696
Schneeweiss Stem Cell Fund: C029572
Foundation Fighting Blindness: C-NY05-0705-0312
Date 2017
Published in American Journal Of Ophthalmology. New York, v. 180, p. 117-123, 2017.
ISSN 0002-9394 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 117-123
Origin http://dx.doi.org/10.1016/j.ajo.2017.05.026
Access rights Closed access
Type Article
Web of Science ID WOS:000406990000017
URI http://repositorio.unifesp.br/handle/11600/51468

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