Genetic variants in gastric cancer: Risks and clinical implications

Genetic variants in gastric cancer: Risks and clinical implications

Author Gigek, Carolina Oliveira Autor UNIFESP Google Scholar
Calcagno, Danielle Queiroz Google Scholar
Rasmussen, Lucas Trevizani Google Scholar
Santos, Leonardo Caires Autor UNIFESP Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Wisnieski, Fernanda Autor UNIFESP Google Scholar
Burbano, Rommel Rodriguez Google Scholar
Lourenco, Laercio Gomes Autor UNIFESP Google Scholar
Lopes-Filho, Gaspar Jesus Autor UNIFESP Google Scholar
Cardoso Smith, Marilia Arruda Autor UNIFESP Google Scholar
Abstract Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC.
Keywords Gastric cancer
mRNA expression
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESp: 2011/22548-2
FAPESP: 2012/14768-5
FAPESP: 2016/19953-6
CNPq: 305220/2013-6
CNPq: 303871/2014-8
Date 2017
Published in Experimental And Molecular Pathology. San Diego, v. 103, n. 1, p. 101-111, 2017.
ISSN 0014-4800 (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 101-111
Access rights Closed access
Type Revisão
Web of Science ID WOS:000408182800015

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