Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

Author Sartori, Michelle Google Scholar
Conti, Filipe F. Google Scholar
Dias, Danielle da Silva Google Scholar
dos Santos, Fernando Google Scholar
Machi, Jacqueline F. Google Scholar
Palomino, Zaira Autor UNIFESP Google Scholar
Casarini, Dulce E. Autor UNIFESP Google Scholar
Rodrigues, Bruno Google Scholar
de Angelis, Kytia Google Scholar
Irigoyen, Maria-Claudia Google Scholar
Abstract Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stressmarkers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups

however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues

decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.
Keywords obesity
cardiac dysfunction
autonomic
inflammation
female
Language English
Sponsor CAPES
CNPq
FAPESP
CNPq Fellowship (CNPq-BPQ)
Grant number CNPq: 457200/2014-6
CNPq: 401781/2012-7
CNPq: 479076/2012-0
CNPq: 563961/2010-4
FAPESP: 2015/11223-6
FAPESP: 2011/15828-9
FAPESP: 2010/17188-4
Date 2017
Published in Frontiers In Physiology. Lausanne, v. 8, p. -, 2017.
ISSN 1664-042X (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fphys.2017.00572
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000408244600001
URI http://repositorio.unifesp.br/handle/11600/51377

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