The intensive care medicine research agenda on septic shock

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dc.contributor.author Perner, Anders
dc.contributor.author Gordon, Anthony C.
dc.contributor.author Angus, Derek C.
dc.contributor.author Lamontagne, Francois
dc.contributor.author Machado, Flavia [UNIFESP]
dc.contributor.author Russell, James A.
dc.contributor.author Timsit, Jean-Francois
dc.contributor.author Marshall, John C.
dc.contributor.author Myburgh, John
dc.contributor.author Shankar-Hari, Manu
dc.contributor.author Singer, Mervyn
dc.date.accessioned 2019-08-19T11:49:30Z
dc.date.available 2019-08-19T11:49:30Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1007/s00134-017-4821-1
dc.identifier.citation Intensive Care Medicine. New York, v. 43, n. 9, p. 1294-1305, 2017.
dc.identifier.issn 0342-4642
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51344
dc.description.abstract Septic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field. en
dc.description.sponsorship Ferring Pharmaceuticals
dc.description.sponsorship Fresenius Kabi
dc.description.sponsorship CSL Behring
dc.description.sponsorship Orion Pharmaceuticals
dc.description.sponsorship Amomed
dc.description.sponsorship Tenax Therapeutics
dc.description.sponsorship HCA International
dc.description.sponsorship NIHR
dc.description.sponsorship NIHR Research Professorship award
dc.description.sponsorship Abbott
dc.description.sponsorship Bayer
dc.description.sponsorship Beckman-Coulter
dc.description.sponsorship Biocartis
dc.description.sponsorship GenMark
dc.description.sponsorship GlaxoSmithKline
dc.description.sponsorship Sobi
dc.description.sponsorship Ferring
dc.description.sponsorship Baxter Healthcare
dc.description.sponsorship Practitioner Fellowship from the National Health and Medical Research Council of Australia
dc.description.sponsorship Grifols
dc.description.sponsorship La Jolla Pharmaceuticals
dc.description.sponsorship CytoVale Inc.
dc.description.sponsorship Asahi Kesai Pharmaceuticals of America (AKPA)
dc.description.sponsorship National Institute for Health Research Clinician Scientist Award
dc.description.sponsorship UK Department of Health
dc.format.extent 1294-1305
dc.language.iso eng
dc.publisher Springer
dc.rights Acesso restrito
dc.subject Clinical research en
dc.subject Critical care en
dc.subject Intensive care en
dc.subject ICU en
dc.subject Randomized trials en
dc.subject Sepsis en
dc.subject Septic shock en
dc.title The intensive care medicine research agenda on septic shock en
dc.type Artigo
dc.description.affiliation Univ Copenhagen, Dept Intens Care, Rigshosp, Copenhagen, Denmark
dc.description.affiliation Imperial Coll London, Dept Surg & Canc, Sect Anaesthet Pain Med & Intens Care, London, England
dc.description.affiliation Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA
dc.description.affiliation Univ Sherbrooke, Fac Med & Sci Sante, Dept Med, Ctr Rech,CHU Sherbrooke, Sherbrooke, PQ, Canada
dc.description.affiliation Univ Fed São Paulo, São Paulo, Brazil
dc.description.affiliation Univ British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada
dc.description.affiliation Univ Paris Diderot, ICU,Bichat Univ Hosp, APHP,Med & Infect Dis, Inserm,UMR 1137,IAME, Paris, France
dc.description.affiliation Univ Toronto, St Michaels Hosp, Dept Surg & Crit Care Med, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada
dc.description.affiliation Univ New South Wales, St George Clin Sch, George Inst Global Hlth, Sydney, NSW, Australia
dc.description.affiliation Kings Coll London, Dept Immunobiol, Guys & St Thomas Hosp NHS Fdn Trust, London, England
dc.description.affiliation UCL, Bloomsbury Inst Intens Care Med, Div Med, London, England
dc.description.affiliationUnifesp Univ Fed São Paulo, São Paulo, Brazil
dc.description.sponsorshipID National Institute for Health Research Clinician Scientist Award: CS-2016-16-011
dc.identifier.doi 10.1007/s00134-017-4821-1
dc.description.source Web of Science
dc.identifier.wos WOS:000408116700010



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