Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition

Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition

Author Martins, Vinicius J. B. Google Scholar
Sesso, Ricardo Autor UNIFESP Google Scholar
Clemente, Ana P. G. Google Scholar
Fernandes, Mariana B. F. Autor UNIFESP Google Scholar
Sawaya, Ana L. Autor UNIFESP Google Scholar
Abstract Background The objective of this study was to investigate some biomarkers of renal function and blood pressure in children who had recovered from undernutrition. Methods This was cross-sectional, comparative study in which a convenience sample of children of both genders (n = 126

age range 6-16 years) treated at the Centre for Nutritional Recovery and Education (Sao Paulo, Brazil) was used. These children were classified into four groups for analysis: (1) children who were well nourished (control group

n = 50), (2) those showing stunted growth (stunted group

n = 22), (3) those who were underweight (underweight group

n = 23) and (4) those who had recovered from undernutrition (recovered group

n = 31). Results No between-group differences were found for mean levels of albuminuria, serum creatinine and cystatin C, and similar mean estimates of glomerular filtration rate (eGFR

using either creatinine, cystatin C or both). Almost 14% of the stunted group, 4% of the underweight group and 3% of the recovered group had albuminuria of >30 mg/g creatinine chi-square p = 0.034)

none of the control children showed albuminuria of >30 mg/g creatinine. Mean systolic (SBP) and diastolic blood pressure (DBP) adjusted for age and gender of the children in the stunted [ SBP (95% confidence interval): 92 (88-96) mmHg

DBP: 47 (44-49) mmHg] and recovered [ SBP: 93 (90-96) mmHg

DBP: 49 (47-51) mmHg] groups were significantly lower than those of the controls [ SBP: 98 (95-100) mmHg, P = 0.027

DBP: 53 (5255) mmHg, P = 0.001]. After additional adjustment for height, mean DBP remained significantly lower in the recovered group compared with the control group [ 49 (46-51) vs. 53 (51-55) mmHg, respectively

P = 0.018). Logistic regression analysis showed that the stunted group had a 8.4-fold higher chance of developing albuminuria (>10 mg/g creatinine) than the control children (P = 0.006). Conclusions No alterations in renal function were found in underweight children and those who had recovered from undernutrition, whereas children with stunted growth presented with a greater risk for albuminuria. A lower DBP was found in children with stunted growth and those who had recovered from undernutrition.
Keywords Renal function
Blood pressure
Undernutrition
Stunting
Underweight
Nutritional recovery
Language English
Sponsor FAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo, Brazil)
CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)
CNPQ (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
Grant number FAPESP: 2010/51237-2
CNPq: 302740/2010-4
Date 2017
Published in Pediatric Nephrology. New York, v. 32, n. 9, p. 1555-1563, 2017.
ISSN 0931-041X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1555-1563
Origin http://dx.doi.org/10.1007/s00467-017-3602-y
Access rights Closed access
Type Article
Web of Science ID WOS:000408418900011
URI http://repositorio.unifesp.br/handle/11600/51333

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